The role of periodontal disease in formation of atherosclerotic lesion

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We clinically and etiologically investigated the bidirectional causality between atherosclerotic lesion in lifestyle-related disease and periodontal disease. Intracardiac calcification severity was positively correlated with the degrees of periodontal disease. Moreover, a statistically significant increase of 11β-HSD1 mRNA expression was detected in the periodontal disease group compared with the controls. Furthermore, the depth of periodontal pockets significantly correlated with the increased expression of 11β-HSD1 mRNA. These results suggest that the increased expression of11β-HSD1 may play a role in the bidirectional causality between atherosclerotic lesion and periodontal disease.