Biochemical and immunological studies on human hepatocellular carcinoma-Relation to integration of HBV-DNA.

研究了碳水化合物抗原在人肝组织和肝细胞癌中的表达。L.肝细胞癌与糖脂质的定量变化有关。2. 通过对表征良好的糖类抗原，即血型相关抗原的研究，得到以下结论。1)血型抗原可通过胆道上皮细胞表达，但不能通过肝细胞表达。2)胆道上皮细胞表达一系列1型链血型抗原和二聚焦型2型链抗原。3)血型抗原的表达与胆管大小有关。这一观察暗示了

Expression of carbohydrate antigens in human liver tissues and hepatocelular carcinomas was studied. L. Hepatocellular carcinoma was associated with the qualitative and quantitative changes of glycolipids. 2. From the study on the well characterized carbohydrate antigens, i.e., blood group-related antigens, the following conclusions were obtained. 1) Blood group antigens were expressed by biliary epithelial cells, but not by liver cells. 2) Biliary epithelial cells expressed a series of type 1 chain blood group antigens and difucosylated type 2chain antigens. 3) Expression of blood group antigens depended on the size of the bile ducts. This observation implied the