Morphometric studies of the axonal processes and nerve cell bodies of the spinal dorsal root ganglion neurons in rats

大鼠脊髓背根神经节神经元轴突和神经细胞体的形态测量研究

基本信息

项目摘要

The primary sensory neuron plays an important role in both somatic and visceral afferent nervous functions. In this study. the primary sensory neuron was morphometrically evaluated to reveal 1)the subclasses of nerve fibers at the level of the sural nerve and trird sacral dorsal root and of nerve cell bodies at the third sacral dorsal root ganglion in control rats and 2)the subclasses of nerve fibers and nerve cell bodies lost in capsaicin-intoxicated rats. In the sural nerve the numbers per nerve of large (<4.3<micrn>m), small myelinated (<equal or less than>4.3<micrn>m) and unmyelinated fibers were 660 <plus-minus> 118 (mean <plus-minus> standard deviation), 377 <plus-minus> 46 and 3,856 <plus-minus> 570, respectively, In the third sacral dorsal root, the numbers per root of large (>6.3<micrn>m), small myelinated (<equal or less than>m) and unmyelinated fibers were 641 <plus-minus> 82, 667 <plus-minus> 126 and 3,303 <plus-minus> 541, respectively. In the third sacral dorsal root ganglion, the numbers per ganglion of large and small nerve cell bodies were 613 <plus-minus> 115 and 1,684 <plus-minus> 72, r~ホモ ヘンカシ 、 2In rats administered with the single subcutaneous capsaicin (50 mg/kg), the number per nerve of unmyelinated fibers was 1,232 <plus-minus> 233 and significantly (P<0.0001) less than in control in the sural nerve, the numbers of small myelinated and unmyelinated fibers per root were 542 <plus-minus> 81 and 895 <plus-minus> 245, respectively and significantly (P<0.04 and P<0.0001, respectively) less than in control in the third sacral dorsal root and the number of small nerve cell bodies per ganglion was 860 <plus-minus> 285 and significantly (P<0.0003) less than in control. Therefore, the small spinal sensory neuron degenerates and is lost in capsaicin-intoxicat377 <pluThe morphometric analysis of the primary sensory neuron is useful for the studies of the pathogenetic mechanisms of the numan and experimental neuropathies.
初级感觉神经元在躯体和内脏传入神经功能中起重要作用。本研究对初级感觉神经元进行形态测定评价,以揭示1)对照大鼠中腓肠神经和第三骶背根水平的神经纤维的亚类以及第三骶背根神经节的神经细胞体的亚类,和2)辣椒素中毒大鼠中丧失的神经纤维和神经细胞体的亚类。在腓肠神经中,每根大(&lt;<micrn>4.3m)、小(<equal or less than>4.3m<micrn>)和无髓纤维数分别为<plus-minus>660118(平均<plus-minus>标准差)、<plus-minus>37746和3856570<plus-minus>。在第三骶后根中,每根大(&gt; <micrn>6.3m)、小(<equal or less than>m)和无髓纤维数分别为<plus-minus>64182、<plus-minus>667126和<plus-minus>3303541。在第三骶背根神经节中,每个神经节的大小神经细胞体的数目分别为<plus-minus>613115和168472<plus-minus>。2在皮下注射辣椒素(50 mg/kg)的大鼠中,腓肠神经中每个神经的无髓纤维的数目为1232233<plus-minus>,显著(P&lt;0.0001)低于对照组;第三骶背根中每个神经根的小的有髓和无髓纤维的数目分别为<plus-minus>54281和895245<plus-minus>,显著(P&lt;0.04和P&lt;0.0001)低于对照组;每个神经节的小神经细胞体的数目为<plus-minus>860285,显著(P&lt;0.0003)低于对照组。因此,辣椒素中毒引起脊髓感觉神经元变性和丢失。初级感觉神经元的形态计量学分析有助于神经病理学和实验性神经病发病机制的研究。

项目成果

期刊论文数量(16)
专著数量(0)
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Ohnishi A, Yamamoto T, Itoyama Y, Murai Y: "Alterations of the nerve fiber populations in the third sacral ventral and dorsal roots in capsaicin-intoxicated rats." Journal of Neurological Sciences.
Ohnishi A、Yamamoto T、Itoyama Y、Murai Y:“辣椒素中毒大鼠第三骶骨腹侧和背侧神经纤维群的改变。”
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大西 晃生,山本 辰紀,村井 由之,糸山 泰人: 神経病理学. 7. 17- (1986)
Akio Onishi、Tatsunori Yamamoto、Yoshiyuki Murai、Yasuto Itoyama:神经病理学。7. 17- (1986)
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Ohnishi A, Yamamoto T, Itoyama Y, Murai Y: "Preferential loss of small diameter nerve cell bodies in the third sacral dorsal root ganglion in capsaicin-intoxicated rats." Journal of Neurological Sciences.
Ohnishi A、Yamamoto T、Itoyama Y、Murai Y:“辣椒素中毒大鼠第三骶骨背根神经节中小直径神经细胞体优先丧失。”
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Ohnishi A, Yamamoto T,Itoyama Y,Murai Y: J Neurol Sci.
Ohnishi A、Yamamoto T、Itoyama Y、Murai Y:神经科学杂志。
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Ohnishi A, Yamamoto T, Murai Y, Itoyama Y: "Morphometric studies of the myelinated fibers of the sural nerve and the third sacral dorsal root and nerve cell bodies of the third sacral dorsal root ganglion in capsaicen-intoxicated rats." Neuropathology. 7.
Ohnishi A、Yamamoto T、Murai Y、Itoyama Y:“辣椒素中毒大鼠腓肠神经和第三骶骨背根神经节的有髓纤维和神经细胞体的形态测量研究。”
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OHNISHI Akio其他文献

OHNISHI Akio的其他文献

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{{ truncateString('OHNISHI Akio', 18)}}的其他基金

Morphometric analysis of primary sensory neuron in aged rats
老年大鼠初级感觉神经元的形态测量分析
  • 批准号:
    62480209
  • 财政年份:
    1987
  • 资助金额:
    $ 3.58万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
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