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Morphometric analysis of primary sensory neuron in aged rats

老年大鼠初级感觉神经元的形态测量分析

基本信息

批准号：
62480209
负责人：
OHNISHI Akio
金额：
$ 3.39万
依托单位：
University of Occupational and Environmental Health, Japan
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1987
资助国家：
日本
起止时间：
1987 至 1988
项目状态：
已结题

项目摘要

In the comparative morphometric studies of the primary sensory neuron between young and old rats, the following conclusions were obtained. In older rats compared with younger rats, 1)the number of myelinated fibers was decreased, 2)the myelin sheath showed segmental demyelination followed by remyelination, 3)the myelin change was severe in the ventral root, 4)axonal degeneration of the myelinated fiber was more frequently found, 5)the nerve cell body in the spinal dorsal root ganglion showed higher density and shrinkage of the cytoplasm, 6)axonal swellings and spheroids were frequently found in the gracile nucleus of the medulla, but they were rare in the dorsal born of the lumbar spinal cord and in the dorsal nucleus of clarke of the first lumbar spinal cord, 7)the volume density of the nerve terminal was decreased in the gracile nucleus of the medulla, dorsal born of the lumbar spinal cord and dorsal nucleus of clarke of the first lumbar spinal cord, and the decrease was prominent in the gracile nucleus, 8)the total number of nerve cell bodies in the first sacral dorsal root ganglion was decreased, and the decrease of those with larger diameters was prominent, and 9)the unmyelinated fibers showed the tendency of the decrease in number, but the ongoing degenerative findings of unmyelinated fibers were not found. Therefore, it was concluded that the primary sensory neuron shows histopathological alterations in each component of the myelin sheath, axon, nerve terminal and nerve cell body. The large diameter sensory neuron seems to be most vulnerable in the aging process.

通过对幼龄和老年大鼠初级感觉神经元形态计量学的比较研究，得出以下结论。老龄大鼠与年轻大鼠相比，1)髓鞘数量减少，2)髓鞘出现节段性脱髓鞘后再髓鞘形成，3)腹侧根髓鞘髓鞘改变严重，4)髓鞘纤维轴突变性较多，5)脊髓背根神经节神经细胞体密度增大，细胞质萎缩，6)髓质细核轴突肿胀，球状体多见。但他们是罕见的背生腰椎脊髓和背侧核的克拉克的第一腰椎脊髓,7)神经终端的体积密度降低的细长的核髓质,背生的克拉克的腰椎脊髓和背侧核第一腰椎脊髓和减少在细长的核,8)的总数第一骶神经细胞体背根神经节是减少,9)无髓鞘纤维有数量减少的趋势，但未见无髓鞘纤维持续退行性表现。因此，我们认为初级感觉神经元在髓鞘、轴突、神经末梢和神经细胞体的各个组成部分都表现出组织病理改变。大直径感觉神经元似乎在衰老过程中最脆弱。