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Experimental application of the antithrombotic materials to the bypass graft in coronary surgery

抗血栓材料在冠状动脉搭桥术中的实验应用

基本信息

批准号：
60480316
负责人：
OKAMOTO YOSHIFUMI
金额：
$ 3.97万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1986
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60480316/
关键词：
Small-caliber prosthesis Polyurethane Acrylamide Antithrombotic SEM 白血球粘着

项目摘要

Coronary revascularization using the artificial graft is very difficult because of its low patency. The thrombogenic nature of prosthetic material used in vascular reconstructive operations limits the patency of grafts, particularly of small-caliber vascular grafts.We have demonstrated that polyurethane bound with polyacrylamide, non-ionic water-soluble polymers, did not obsorb protein nor platelets adhere in vitro experiments and did not cause thrombus formation implanted in rat carotid artery.The aim of the present study was focused on the analysis about thrombo resistance of synthetic polymeric materials and development of a new vascular prosthesis which was able to use for the aortocoronary bypass graftiny. Using mongrel dogs, the prosthesis, polyurethane bound with polyacrylamide were implanted into the carotid, femoral or iliac arteries. A dose of aspirin 40mg/kg, a platelet aggregation inhibitor was administered intravenously before surgery.The graft patendy was observed in all. The inner surfaces of them were observed optically scaned electromicroscopically.30 minutes 1 hour and 2 hours after surgery, entire surfaces were covered with deformed white blood cell without platelet adhesion. 22 hours after implantation white blood cells were destructed completely and covered with diffuse thin layer.From these results, it was concluded that polyurethane coupled with non-ionic water-soluble polyacrylamide might not be complete blood compatible.

由于其通畅率低，使用人工移植物进行冠状动脉血运重建非常困难。血管重建手术中使用的假体材料的血栓性质限制了移植物的通畅，特别是小口径血管移植物的通畅。我们已经证明，与非离子水溶性聚合物聚丙烯酰胺结合的聚氨酯在体外实验中不吸附蛋白质，也不粘附血小板，并且不会导致植入大鼠颈动脉中的血栓形成。研究重点是分析合成高分子材料的抗血栓性以及开发能够用于主动脉冠状动脉搭桥术的新型血管假体。使用杂种狗，将与聚丙烯酰胺结合的聚氨酯假体植入颈动脉、股动脉或髂动脉中。术前静脉注射阿司匹林40mg/kg，血小板聚集抑制剂，观察移植物通畅情况。光学扫描电镜观察其内表面。术后30分钟、1小时和2小时，整个表面布满变形的白细胞，无血小板粘附。植入后22小时，白细胞被完全破坏，并覆盖有弥漫的薄层。从这些结果可以得出结论，聚氨酯与非离子水溶性聚丙烯酰胺的结合可能不完全血液相容。