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Responses of biogenic amines,cell-mediated immunity and cerebral metabolism in Multiple Organ Failure condition.

多器官衰竭状态下生物胺、细胞免疫和脑代谢的反应。

基本信息

批准号：
60480343
负责人：
MITSUHATA Hiromasa
金额：
$ 4.1万
依托单位：
University of Akita
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1987
项目状态：
已结题

项目摘要

Serotonin and Angiotensin converting enzyme were mesured to eclucidate the metabolic function of lung in acute respiratory failure. Absorption rate to lung of Serotonin in comtrol group is 45.3<plus-minus>22.3% compared to -2.6<plus-minus>61.8 in ARF. There is not significant between two groups. ACE in acute respiratory failure is lower ,20.1<plus-minus>10.7, than 30.8<plus-minus>6.0 U/ml in control group. There is significant between two groups(P<0.05). Angiotensin converting enzyme is good indicator for disturbance of metabolic function of lung in acute respiratory failure with MOF. Decrease of ACE may explain to the extent of functional involvement of the epithelial cell of pulmonary vキノウハキョIn MOF with over two organs consumption of complements may be appered but is not firmly admitted. There is not significant between alive group and dead one. In cell-mediated immunity function of T cell is severely inhibited both groups. In alive group OKT4+,OKT8+ percentage are maintained within normal range. However in dead group those surface antigens decreased below normal range, especially OKT4+ apparantly decreased at stastical significant(p .05). Ration OKT4+/8+ seemingly show normally. This normality is due to decrease of OKT8+ according with the decrease of OKT4+. B cell(OKIa1) maintained normally during clinical course both groups. The main causes of secondary immunodeficiency in MOF are the inhibition of T cell function and the decrease nember of T cells. Therefore to observe the influence to OKT4+ and OKT8+ T cell, it is possible to know the degree of secondary immunodeficiency of MOF.

测定5-羟色胺和血管紧张素转换酶在急性呼吸衰竭时肺代谢功能的变化。对照组5-羟色胺肺吸收率为45.3±22.3%，ARF组为-2.6±61.8%。两组间差异无统计学意义。急性呼吸衰竭患者ACE值为20.1±10.7 U/ml，低于对照组的30.8±6.0 U/ml。两组比较差异有统计学意义(P&lt；0.05)。血管紧张素转换酶是急性呼吸衰竭合并多器官功能衰竭时肺代谢功能紊乱的良好指标。血管紧张素转换酶的降低可能解释了多器官功能衰竭时肺v-キノウハキョ上皮细胞的功能受累程度。补体的摄入可能是可能的，但不一定是肯定的。活组与死组之间差异不显著。在细胞免疫功能方面，两组T细胞均受到严重抑制。存活组OKT4+、OKT8+百分率均维持在正常范围。死亡组上述表面抗原均低于正常范围，尤以OKT4+明显降低，差异有统计学意义(P<0.05)。定量OKT4+/8+似乎显示正常。这种正常是由于OKT8+的减少与OKT4+的减少所致。B细胞(OKIa1)在两组患者的临床过程中均维持正常。继发性免疫缺陷的主要原因是T细胞功能抑制和T细胞数量减少。因此，观察MOF对OKT4+、OKT8+T细胞的影响，可以了解MOF继发性免疫缺陷的程度。