Study on multiphase biomedical materials compatible with bone tisse in oral surgery

我们开发了一种多相材料，由羟基磷灰石（HAP）、聚（2,2,2-三氟乙基甲基丙烯酸酯）（PTFEMA）和金属芯组成，用于牙种植体和骨替代品。我们的研究表明，(1)HAP- ptfema复合材料含有70%的HAP颗粒，具有与骨近似的弹性，这些复合材料与内部金属芯结合具有很高的强度和韧性。(2)这些材料没有细胞毒性，对组织刺激小，骨组织亲和力好（与骨直接结合）。在这些测试结果的基础上，我们开发了一种牙种植体和一种骨替代物用于下颌骨重建。我们的研究表明，(3)人工牙种植体的表面由该复合材料与内部空间具有应力断裂结构的钛管结合而成，经计算机分析表明，该复合材料具有生物迁移性、良好的应力分散和减震性能。(4)该复合材料构建的人工骨易于加工和操作；(5)其临床应用效果良好。

We have developed a multiphase material consisting of hydroxyapatite [HAP],poly(2,2,2-trifluoroethyl metacrylate)[PTFEMA],and a metal core for use as a dental implant and bone substitute .Our studies showed that,(1) HAP-PTFEMA composite materials containing 70 wt% of HAP particles have approximately the same elasticity as bone ,and these composite materials bonded to an inner metal core have great strength and toughness . (2) These materials showed no cytotoxity,litlle tissue irritation , and good bone-tissue affinity ( direct bonding with bone ) .On the basis of these test results, we have developed a dental implant and a bone substitute for mandibular reconstruction .Our studies indicate that,(3) the dental implant, the surface of which consistes of this composite material bonded to a titanium tube having stress breaking structures in its inner space, showed biological mobility, good stress dispersion and shock absorption when subjected to computer analysis .(4) The artificial bone constructed of this mutiphas material was easily processed and manipulated,and(5)its clinical application yielded good results .