Study on multi-phase artificial jaw and dental implant materials with soft-tissue affinity and biofunctionality

为了提高人工材料的软组织亲和性，获得与周围组织如牙龈的紧密附着，我们尝试将胶原蛋白固定在材料表面。胶原蛋白固定是通过等离子体聚合装置进行的，该装置是用科学研究资助购买的。首先，我们建立了合适的预处理和等离子体聚合条件。通过这种方法，胶原蛋白通过共价键与材料连接，即使在生物体等潮湿环境中，也可以将胶原蛋白牢固且长期稳定地固定在材料表面。然后将胶原固定的多孔聚乙烯片皮下植入大鼠背部，观察组织学反应。因此。结缔组织在植入后很快生长到多孔聚乙烯片的孔隙中，组织向内生长的速度大大提高。更多d.周围组织与材料的附着，在材料-组织界面处，观察到生物体来源的胶原纤维牢固地附着在材料表面。这种情况在植入后持续了一年多。因此，该方法在提高人工材料的软组织亲和性方面是非常有效的，提示该方法具有临床应用的可能性。同时，通过提供天然牙齿和骨组织所具有的畸形和抗冲击等生物功能，提高牙种植体和人工颌骨的生物力学相容性。我们使用科学研究资助购买的有限元分析系统，分析了天然牙齿和骨骼在功能应力下的力学响应。结果表明，牙周膜在静载荷作用下具有分散骨窝周围应力的作用，在动载荷作用下具有吸收冲击的作用。此外，这些结果表明，种植牙应该在根内设计一个减震结构，使其能够像天然牙齿一样提供物理位移和减震功能，以弥补牙周膜的功能。根据这些结果，我们开发了一种新的种植牙。它的根部有一个减震结构，我们检查了它的实际位移和减震能力。我们的研究结果表明，新的种植体具有更大的位移和显着更高的吸震性，因此我们期望这种种植体在临床使用中将是非常有效的

In order to improve the soft-tissue affinity of artificial materials and to obtain a tight attachment of surrounding tissue such as gingiva, we tried to immobilize collagen onto the surface of materials. Collagen-immobilization was performed by a plasma-polymerizing apparatus, which had been purchased with grant-in-aid for scientific research. First, we set up the proper conditions for pretreatment and plasma polymerization. By means of this method, collagen wad connected with materials by covalent bonding, and it became possible to immobilize collagen firmly and with long-term stability onto the surface of materials even in a moist environment such as a living body. Then, collagenimmobilized porous polyethylene pieces were implanted subcutaneously in the backs of rats, and subsequent histological reactions were examined.As a result. connective tissue grew into the pores of the porous polyethylene pieces soon after implantation, and the rate of tissue ingrowth was substantially improve … More d. The surrounding tissue attached itself to the material, and at material-tissue interface living-body-originated collagen fibers were observed to be firmly attached to the surface of the material. This condition continued for more than one year after implantation. Therefore this method proved to be very effective in improving the soft-tissue affinity of artificial materials, suggesting possibility that this method could be clinically applied.At the same time, to improve biomechanical compatibility of dental implants and artificial jaw bones by providing biofunctionality such as deformity and shock-absorbablity such as that possessed by natural teeth and bony tissue. we analyzed the mechanical response of natural teeth and bones under functional stress using a finite element analysis system, which was purchased with grant-in-aid for scientific research.The result indicated that the periodontal membrane plays a role in dispersing stress around the bony sockets of teeth under a static load and absorbing shock under a dynamic load. Moreover, these results suggested that dental implants should be designed with a shock-absorbing structure inside the root, which could provide physical displacement and shock-absorbability like natural teeth in order to compensate for the function of the periodontal membrane. Following these results, we developed a new dental implant. which has a shock-absorbing structure inside the root, and we examined its actual displacement and shock-absorbability.Our findings indicated that the new dental implant had a larger displacement as well as a remarkably higher shock-absorbability Therefore, we expect that this implant will be very effective in clinical use Less