Vitamin D induces a dynamic and celltype-specific modulation of the 3D- chromatin structure
Vitamin D induces a dynamic and celltype-specific modulation of the 3D- chromatin structure
批准号:
437173059
负责人:
Dr. Sabine Seuter
金额:
$0.0万
依托单位:
依托单位国家:
德国
项目类别:
Research Grants
财政年份:
2020
资助国家:
德国
项目状态:
已结题
起止时间:
2019-12-31 至 2022-12-31
中文摘要
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英文摘要
This project aims to prove that the insulation of DNA loci by CTCF is the basis for a context-dependent vitamin D signaling. Modern, state- of-the art methods like HiChIP, ChIPmentation, RNA-seq, RIME and CRISPR/Cas9 will be used for this approach. The main objective is to study the extent to which the situation- and tissue-specific gene regulation by vitamin D is determined or modulated by the insulator function of CTCF.
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