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Studies on the constituents of Thai medicinal plants

泰国药用植物成分研究

基本信息

批准号：
61470146
负责人：
SAKAI Shin-ichiro
金额：
$ 3.97万
依托单位：
Chiba University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1986
资助国家：
日本
起止时间：
1986 至 1988
项目状态：
已结题

项目摘要

Chemical studies of the constituents of some Thai medicinal plants, mainly focused on indole alkaloids, were carried out based on our botanical survey in 1984.1. New type seco alkaloids of Uncaria salaccensis; From this Rubiaceae plant four new alkaloids were obtained. Three of them possessed the novel 20,21-dioxo-20,21-secoframework modified from the conventional oxindole alkaloid structure. The remaining one was a 3-oxo-7-hydroxy-3,7-seco-type alkaloid.2. Alkaloids of Kopsia jasminiflora; Five new alkaloids were isolated. Kopsijasminilam was an alkaloid having the novel 20-hydroxy-21-oxo-20,21-seco-aspidofractinine skeleton. Deoxykopsijasminilam and ^<14>-kopsijasminilam were additional members of the same structural class of alkaloids.3. Chemical studies on the alkaloids of Gelsemium elegans; Eight new alkaloids were found in the titled Loganiaceae plant and their structures were determined. The structure of koumidine which was previously presented was revised. Studies on biogenetically patterned synthesis of this gruop of alkaloids were also carried out.4. Constituents of a bitter plant, Vernonia extensa; A new type sterol glucoside was found in the titled compositae plant. Chemical and spectroscopical studies clarified that this compound had a tetracyclic sterol framework possessing <@17,9(11)<@D1-heteroannular conjugated diene and a novel highly-oxygenated side chain structural moiety.

根据1984年的植物学调查，对泰国一些药用植物的成分进行了化学研究，主要集中在吲哚生物碱上。从该茜草科植物中分离得到四种新生物碱。其中三个化合物具有由传统的吲哚生物碱结构改造而来的新型20，21-二氧代-20，21-开环骨架。剩下的一个是3-氧代-7-羟基-3，7-开环型的生物碱。茉莉花石松的生物碱;分离得到五个新生物碱。Kopsijasminilam是具有新的20-羟基-21-氧代-20，21-断-aspidofractinine骨架的生物碱。Deoxykopsijasminilam和^<14>-kopsijasminilam是相同结构类别的生物碱的额外成员。钩吻生物碱的化学研究从马钱科植物中发现8个新生物碱，并对其结构进行了鉴定。对以前报道的koumidine的结构进行了修正。并对该类生物碱的生物合成模式进行了研究.苦药斑鸠菊的化学成分研究在菊科植物斑鸠菊中发现一种新的甾醇苷。化学和光谱研究表明，该化合物具有一个四环甾醇骨架，含有<@17，9（11）<@D1-杂环共轭二烯和一个新的高含氧侧链结构部分。