Study on mechanism of development of nasal hyperreactivity in nasal allergy.

本文对日本雪松花粉症患者和卵清蛋白致敏的豚鼠进行了抗原攻击后鼻腔粘液和鼻灌洗液中炎性细胞和化学介质的动力学研究。观察了抗原攻击和各种化学介质鼻腔攻击后鼻腔对组胺的反应性变化和鼻黏膜自体神经受体的变化。目前的研究表明，鼻变态反应性鼻黏膜的高反应性是由化学介质直接诱导的，特别是SRS-A和PAF的直接作用，是由鼻黏膜上神经受体密度的改变和继发于化学介质诱导的各种炎症细胞引起的。减敏治疗导致鼻腔对组胺的反应性显着降低，这与抗原攻击后鼻灌洗液中炎性细胞的显着减少是一致的。

Studies were perfomed on kinetics of inflammatory cells, chemical mediators in the nasal mucasa and in the nasal lavage fluid after antigen challenge in subject with Japanese cedar pollinosis and also in guinea pigs sensitized with ovalbumin. Changes of nasal reactivity to histamine and changes of autonamic nerve receptors in the nasal mucosa after antigen challenge and after nasal challenge with various chemical mediators were also avaluated. Present studies indicate that hyperreactuvity of the nasal mucasa characteristic of nasal allergy was induce by direct of chemical mediators, especially of SRS-A and PAF and by the changes of density of outonomic nerve receptors in the nasal mucosa and by various inflammtory cells induced secondarily by chemical mediators. Hyposensitization therapy caused significant decrease of nasal reactivity to histamine which was consistant with significant decrease of inflammatory cells in the nasal lavage fluid after antigen challenge.