Study on mechanism of development of nasal hyperreactivity in nasal allergy.

鼻过敏中鼻高反应发生机制的研究。

• 批准号: 61480354
• 负责人: AKIYOSHI Kinno
• 金额: $ 3.52万
• 依托单位: Chiba University, School of Medicine (1988)Akita University (1986-1987)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1988
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-61480354/
• 关键词: Nasal Hyperreactivity; Inflammatory cells; SRS-A; PAF; Nasal Allergy; Autonomic Nerve Receptors; 好塩基球; 鼻粘膜; 鼻粘膜過敏性; 抗原誘発; 減滅作療法; 抗アレルギー薬療法; 鼻過敏症状; 実験鼻アレルギーモルモット; LTB_4; SRSーA; IgE抗体値; IgG抗体値; 血小板活性因子(PAF) ロイコトリエン

Studies were perfomed on kinetics of inflammatory cells, chemical mediators in the nasal mucasa and in the nasal lavage fluid after antigen challenge in subject with Japanese cedar pollinosis and also in guinea pigs sensitized with ovalbumin. Changes of nasal reactivity to histamine and changes of autonamic nerve receptors in the nasal mucosa after antigen challenge and after nasal challenge with various chemical mediators were also avaluated. Present studies indicate that hyperreactuvity of the nasal mucasa characteristic of nasal allergy was induce by direct of chemical mediators, especially of SRS-A and PAF and by the changes of density of outonomic nerve receptors in the nasal mucosa and by various inflammtory cells induced secondarily by chemical mediators. Hyposensitization therapy caused significant decrease of nasal reactivity to histamine which was consistant with significant decrease of inflammatory cells in the nasal lavage fluid after antigen challenge.

本文对日本柳杉花粉症患者和卵清蛋白致敏豚鼠鼻粘膜和鼻灌洗液中炎性细胞、化学介质的动态变化进行了研究。同时观察了抗原激发后和各种化学介质激发后鼻粘膜对组胺反应性的变化及鼻粘膜自律神经受体的变化。目前的研究表明，鼻变态反应性鼻粘膜反应性的形成是由化学介质，特别是SRS-A和PAF的直接作用，以及鼻粘膜外神经受体密度的改变和化学介质继发的各种炎性细胞引起的。脱敏治疗可使鼻黏膜对组胺的反应性明显降低，这与抗原激发后鼻灌洗液中炎性细胞的明显减少是一致的。

项目成果

寺田修久 他: 日耳鼻.

寺田信久等人：Nichi-otoh-nose。

寺田修久: 日本耳鼻咽喉科学会会報.

Nobuhisa Terada：日本耳鼻喉科学会会刊。

寺田修久 他: 日耳鼻. 91. 847-855 (1988)

N. Terada 等人：Nippon Otohana 91. 847-855 (1988)

寺田修久 他: 日耳鼻. 90. 1196-1207 (1987)

N. Terada 等人：Nippon Otomi。90。1196-1207 (1987)

今野昭義 他: 耳鼻臨床. (1989)

Akiyoshi Konno 等：耳鼻喉科 (1989)