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Histopathological Study on the Healing of Artificially Created Intrabony Defects Following Bone Grafts.-Fresh Autogenous Bone Graft and Freeze-dried Bone Graft-

骨移植后人工骨内缺损愈合的组织病理学研究。-新鲜自体骨移植和冻干骨移植-

基本信息

批准号：
61480402
负责人：
SATO Tetsuichiro
金额：
$ 2.3万
依托单位：
Tokyo Dental College.
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1986
资助国家：
日本
起止时间：
1986 至 1987
项目状态：
已结题

项目摘要

The fresh freeze-dried autogenous iliac cancellous bone and marrow were transplanted into the intrabony defects of rats maxillae. The healing process was studied histopathologically by means of an electron microscope.The results were as follows.1. Day O, the bone marrow cells and osteocytes in the fresh iliac cancellous bone fragments had already degenerated.2. After 3 to 5 days, the fresh iliac cancellous bone fragments were under resorption by the osteoclasts and macrophages. The freeze-dried iliac cancellous bone fragments were under resorption only by the macrophages.3. After 12 days, both fresh and freeze-dried iliac cancellous bone fragments were surrounded by the osteoblasts derived from periosteum of the alveolar bone.4. After 3 to 6 weeks, the intrabony defects had been repaired by the new bone tissues containing the fresh and freeze-dried iliac cancellous bone fragments and the periodontal ligament space had also been reestablished.From these results, it seemed that both fresh and freeze-dried iliac cancellous bone autografts only had an osteoconductive effect.

将新鲜冷冻干燥的自体髂骨松质骨和骨髓移植到大鼠上颌骨的骨内缺损区。用电子显微镜对愈合过程进行了组织病理学研究，结果如下。O天，新鲜的髂骨松质骨碎片中的骨髓细胞和骨细胞已经变性。3~5d后，新鲜的髂骨松质骨碎片被破骨细胞和巨噬细胞吸收。冻干的髂骨松质骨碎片仅被巨噬细胞吸收。12天后，新鲜和冻干的髂骨松质骨碎片均被牙槽骨骨膜来源的成骨细胞包裹。3~6周后，含有新鲜和冻干的髂骨松质骨碎片的新骨组织修复了骨内的缺损区，牙周韧带间隙也得到了重建，表明新鲜和冻干的自体髂骨松质骨移植似乎都只有骨传导作用。