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Experimental and clinical analysis of functional characteristics of intramyocardial microvessls and its disorders

心肌内微血管功能特征及其疾病的实验和临床分析

基本信息

批准号：
62480220
负责人：
KAJIYA Fumiko
金额：
$ 4.35万
依托单位：
Kawasaki Medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1987
资助国家：
日本
起止时间：
1987 至 1988
项目状态：
已结题

项目摘要

The purpose of this study was to clarify the physiological and pathophysiological role of intramyocardial capacitance vessels in the regulation of coronary circulation in animal experiment and clinical research. In anesthetized open-chest dogs coronary inflow(artery flow) coronary outflow(coronary vein flow) were measured by an optical fiber laser doppler velocimeter under control of coronary perfusion pressure. On the other hand, human coronary artery and vein flows were measured by an 80 channel 20 MHz ultrasound doppler velocimeter during cardiac surgery.Functional characteristics of intramyocardial capacitance vessels were composed of two factors: unstressed volumes(UV) and usual compliance. The characteristics of UV is fitted to store blood and its capacity is found to be 5ml/100g of LV. The coronary inflow resistance increased without significant changes of zero-flow pressure, when UV was filled with blood. The phasic coronary vein flow was mainly regulated by the blood stored within intramyocardial vessels. The rheological property of blood had effects on not only inflow resistance but also zero-flow pressure of the coronary artery. The fluid dynamics of the human poststenotic coronary artery folw was analyzed by 20MHz 80 Channel ultrasound Doppler velocimeter during cardiac surgery. the phasic characteristics of coronary artery folw in pressure overload human hypertrophy was also clarified. We developped dual-core optical fiber laser doppler velocimeter, which is useful for the measurement of blood flow away from the fiber and disturbed flow.

本研究的目的是在动物实验和临床研究中阐明心肌内容血管在冠状动脉循环调节中的生理和病理生理作用。在麻醉开胸犬，用光纤激光多普勒测速仪在冠状动脉灌注压控制下测量冠状动脉流入（动脉流量）和流出（静脉流量）。另一方面，在心脏手术中，用80通道20 MHz超声多普勒测速仪测量人冠状动脉和静脉血流，心肌内容量血管的功能特性由两个因素组成：无应力体积（UV）和通常的顺应性。紫外线的特性适合于贮存血液，其容量为5 ml/100 g LV。当UV充满血液时，冠状动脉流入阻力增加，而零流压无明显变化。冠状静脉血流的时相性主要受心肌内血管的血液调节。血液的流变性不仅影响冠状动脉的流入阻力，而且影响冠状动脉的零流压。应用20 MHz 80通道超声多普勒血流仪对心脏手术中冠状动脉狭窄后血流进行了动态分析。阐明了压力超负荷性心肌肥厚时冠状动脉血流的时相特征。研制了双芯光纤激光多普勒测速仪，可用于离纤血流和扰动血流的测量。