22nd Liver Sinusoid Meeting

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ABSTRACT This R13 application requests support for the 22nd Liver Sinusoid Meeting from the International Society for Hepatic Sinusoidal Research (ISCHS), to be on April 24-26, 2024, in the College of Medicine at the University of Illinois at Chicago. The application requests support from NIAAA and NIDDK for the participation of trainees and non-funded early-stage investigators (ESI). The goal of the Liver Sinusoid Meeting is to bring together an international group of multidisciplinary scientists, including established and new investigators, pre- and post- doctoral trainees, who are interested in the common questions: 1) how hepatic sinusoidal liver cells and their crosstalk, contribute to the pathogenesis and resolution of alcohol-associated liver disease (AALD), non- alcoholic fatty liver disease (NAFLD), fibrosis, stimulation or suppression of liver regeneration, regulation of liver microcirculation, and hepatocellular carcinoma (HCC) onset and progression; and 2) how new knowledge from emerging tools applicable to all areas of liver research, such as multiomics, matrisomics, bioengineered liver tissue, organoids, nanotechnologies, and immunomodulation can be used to improve treatments of liver disease. Participants at the meeting will present cutting-edge, high-quality research, which begins to identify novel molecular and cellular interactions within the liver sinusoid. There are surprising gaps in our understanding of this basic unit of functional activity in the liver; advances in hepatic sinusoidal cell biology are critical to understanding the cellular basis of AALD, acute, and chronic liver disease. The ISCHS represents the only international organization, which gathers leading investigators in liver biology and hepatocellular cross talk from around the world. This meeting will facilitate and promote: 1) international collaborations among different countries with populations differing in their genetics and social backgrounds who suffer from AALD, acute, and chronic liver disease; 2) resource sharing among international investigators, generating synergy and unique ideas; and 3) interaction of trainees at the international level. Taken together, the unique environment of the Liver Sinusoid Meeting is an ideal format for cutting-edge interactions on the potential implications of their research into the pathogenesis of AALD, acute, and chronic liver disease, helping to synergize research that will fill these gaps and advance the frontier of research in liver disease, and development of preventative and therapeutic treatments.