22nd Liver Sinusoid Meeting

第22次肝正弦波会议

• 批准号: 10805816
• 负责人: Natalia Nieto
• 金额: $ 2万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-20 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10805816
• 关键词: Acute; Alcoholic Liver Diseases; Alcohols; Anatomy; Area; Award; B-Lymphocytes; Basic Science; Biology; Biomedical Engineering; Cell Communication; Cell physiology; Cells; Cellular biology; Chicago; Clinical Investigator; Clinical Research; Collaborations; Communities; Complex; Country; Data; Development; Developmental Biology; Disabled Persons; Discipline; Discontinuous Capillary; Disease; Endothelial Cells; Environment; Event; Fibrosis; Functional disorder; Genetic; Goals; Health; Hepatic; Hepatic Stellate Cell; Hepatocyte; Hepatology; Illinois; Individual; Inflammation; International; Intoxication; Knowledge; Kupffer Cells; Liver; Liver Fibrosis; Liver Regeneration; Liver diseases; Macrophage; Medicine; Methodology; Microcirculation; Modality; Molecular; Nanotechnology; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Alcohol Abuse and Alcoholism; Natural Killer Cells; Nature; Oncology; Operative Surgical Procedures; Oral; Organoids; Participant; Pathogenesis; Pharmaceutical Preparations; Physicians; Physiology; Population; Postdoctoral Fellow; Primary carcinoma of the liver cells; Regulation; Request for Applications; Research; Research Personnel; Resolution; Resource Sharing; Role; Science; Scientist; Signal Transduction; Societies; Steatohepatitis; T-Lymphocyte; Therapeutic; Tissues; Translational Research; Travel; Universities; Woman; cell type; chronic liver disease; college; ethnic minority; frontier; hepatic sinusoid; immunoregulation; improved; innovation; interest; lectures; meetings; multidisciplinary; multiple omics; non-alcoholic fatty liver disease; novel; novel diagnostics; novel therapeutics; posters; pre-doctoral; racial minority; recruit; response; social; symposium; synergism; tool; translational scientist

ABSTRACT This R13 application requests support for the 22nd Liver Sinusoid Meeting from the International Society for Hepatic Sinusoidal Research (ISCHS), to be on April 24-26, 2024, in the College of Medicine at the University of Illinois at Chicago. The application requests support from NIAAA and NIDDK for the participation of trainees and non-funded early-stage investigators (ESI). The goal of the Liver Sinusoid Meeting is to bring together an international group of multidisciplinary scientists, including established and new investigators, pre- and post- doctoral trainees, who are interested in the common questions: 1) how hepatic sinusoidal liver cells and their crosstalk, contribute to the pathogenesis and resolution of alcohol-associated liver disease (AALD), non- alcoholic fatty liver disease (NAFLD), fibrosis, stimulation or suppression of liver regeneration, regulation of liver microcirculation, and hepatocellular carcinoma (HCC) onset and progression; and 2) how new knowledge from emerging tools applicable to all areas of liver research, such as multiomics, matrisomics, bioengineered liver tissue, organoids, nanotechnologies, and immunomodulation can be used to improve treatments of liver disease. Participants at the meeting will present cutting-edge, high-quality research, which begins to identify novel molecular and cellular interactions within the liver sinusoid. There are surprising gaps in our understanding of this basic unit of functional activity in the liver; advances in hepatic sinusoidal cell biology are critical to understanding the cellular basis of AALD, acute, and chronic liver disease. The ISCHS represents the only international organization, which gathers leading investigators in liver biology and hepatocellular cross talk from around the world. This meeting will facilitate and promote: 1) international collaborations among different countries with populations differing in their genetics and social backgrounds who suffer from AALD, acute, and chronic liver disease; 2) resource sharing among international investigators, generating synergy and unique ideas; and 3) interaction of trainees at the international level. Taken together, the unique environment of the Liver Sinusoid Meeting is an ideal format for cutting-edge interactions on the potential implications of their research into the pathogenesis of AALD, acute, and chronic liver disease, helping to synergize research that will fill these gaps and advance the frontier of research in liver disease, and development of preventative and therapeutic treatments.

摘要 此R13应用程序请求支持第22届肝窦状隙会议， 肝窦研究（ISCHS），将于2024年4月24日至26日在大学医学院举行 伊利诺伊州的芝加哥。该申请要求NIAAA和NIDDK为受训人员的参与提供支持 和非资助的早期研究者（ESI）。肝窦会议的目标是汇集一个 国际多学科科学家小组，包括常设和新的研究人员， 博士生，谁感兴趣的共同问题：1）如何肝窦肝细胞及其 串扰，有助于酒精相关性肝病（AALD）的发病机制和解决，非 酒精性脂肪肝（NAFLD），纤维化，肝再生的刺激或抑制， 肝微循环，和肝细胞癌（HCC）的发病和进展;和2）如何新的知识 从适用于肝脏研究所有领域的新兴工具，如多组学，基质组学，生物工程 肝组织、类器官、纳米技术和免疫调节可用于改善肝脏疾病的治疗。 疾病与会者将提出尖端的，高质量的研究，开始确定 新的分子和细胞的相互作用在肝窦。在我们的研究中， 了解肝脏功能活动的基本单位;肝窦细胞生物学的进展， 这对于理解AALD、急性和慢性肝病的细胞基础至关重要。ISCHS代表 唯一的国际组织，聚集了肝脏生物学和肝细胞交叉研究的领先研究人员 来自世界各地的谈话。本次会议将促进和推动：1）国际合作， 不同国家的人群在遗传学和社会背景上不同，他们患有AALD， 急性和慢性肝病; 2）国际研究者之间的资源共享，产生协同效应 和独特的想法;和3）学员在国际一级的互动。合在一起， 肝窦会议的环境是一种理想的形式， 他们对AALD，急性和慢性肝病发病机制的研究的影响，有助于 协同研究，填补这些空白，推进肝病研究的前沿，以及 预防和治疗的发展。