Interaction between anesthetics and various drugs in the canine blood-perfused papillary muscle and sinoatrial node preparations.

麻醉剂与犬血液灌注乳头肌和窦房结制剂中各种药物之间的相互作用。

• 批准号: 62480326
• 负责人: KUMAZAWA Teruo
• 金额: $ 4.48万
• 依托单位: Yamanashi Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-62480326/
• 关键词: Blood-perfused papillary muscle; Blood-perfused S-Anode preparation; Nicardipine; Enflurane; Vecuronium; Pancuronium; Sevoflurane; Diltiazem; 筋弛緩薬; 陽変力作用; 陽変時作用; イヌ血潅流標本

In the canine isolated, blood-perfused heart preparations the direct effects of the agents which were given even into the donor dog could be observed, while in the donor animal the systemic effects of the agents which would be modified by neurohumoral compensatory reflex mechanisms could be observed.In this model, we observed the interaction between nicardipine and enflurane in 1987. Nicardipine depressed more potently developed tension, heart rate and blood pressure in enflurane anesthetized dogs than in conscious dog.In 1988, we compared the effects of pancuronium and vecuronium in this mode. Both drugs caused dose-dependent positive inotropic and chronotropic effects. These effects were suggested to be mediated by release of norepinephrine from the sympathetic nerve endings.In 1989, we investigated the interaction between diltiazem and sevo- flurane in this model. Both drugs prologed PQ interval and depressed developed tension. These effects were observed to be potentiated by each other drug.

在犬离体血液灌注心脏制备物中，可以观察到甚至给予供体犬的药物的直接作用，而在供体动物中，可以观察到通过神经体液代偿反射机制修饰的药物的全身作用。尼卡地平对安氟醚麻醉犬的张力、心率和血压的抑制作用强于清醒犬。两种药物均引起剂量依赖性正性肌力和变时作用。1989年，我们在这个模型中研究了地尔硫卓与七氟醚之间的相互作用。两种药物均延长PQ间期，降低发展性张力。观察到这些作用通过每种其他药物增强。

项目成果

Manabe, Masanobu. Motomura, Shigeru. and Hashimoto, Keitaro: "Interaction between Diltiazem and Halothane or Enflurane in the Canine Blood-perfused Papillary Muscle and Sinoatrial Node preparations Cross-circulated by Chronically Instrumented Conscious Do

真锅，政信。

Manabe,M.;Motomura,S.;Kumazawa,T.;Ookawa,I.;Oguchi,T.: Journal of Anesthesia. 2. 202-206 (1988)

真锅，M.；本村，S.；熊泽，T.；大川，I.；大口，T.：麻醉杂志。

Manabe,Masanobu.Ookawa,Iwao.Nonaka,Akihiko.and Kumazawa,Teruo.: "Effects of Sevoflurane with or without Nitrous Oxide on Cardiac Contractility and Sinoatrial Node Rate." Journal of Anesthesia.3. 145-148 (1989)

Manabe,Masanobu.Ookawa,Iwao.Nonaka,Akihiko.and Kumazawa,Teruo.：“七氟烷加或不加一氧化二氮对心脏收缩力和窦房结率的影响。”

Manabe, Masanobu. Ookawa, Iwao. Nonaka, Akihiko. and Kumazawa, Teruo.: "Effects of Sevoflurane with or without Nitrous Oxide on Cardiac Contractility and Sinoatrial Node Rate." Journal of Anesthesia, Volume 3, Number 2, 145-148, 1989.

真锅，政信。

Manabe,Masanobu.Motomura,Shigeru.and Hashimoto.Keitaro: "Interaction between Diltiazem and Halothane or Enflurane in the Canine Bllod-perfused Papillary Muscle and Sinoatrial Node preparations Cross-circulated by Chronically Instrumented Conscious Donor D

Manabe，Masanobu.Motomura，Shigeru.和Hashimoto.Keitaro：“地尔硫卓和氟烷或安氟烷在犬血液灌注的乳头肌和窦房结制剂中的相互作用，由慢性仪器清醒供体D交叉循环