Interaction between anesthetics and various drugs in the canine blood-perfused papillary muscle and sinoatrial node preparations.

在犬离体血灌注心脏制剂中，可观察到药物直接作用于供体犬，而在供体动物中，可观察到药物经神经体液代偿反射机制修饰后的全身作用。在这个模型中，我们在1987年观察了尼卡地平和安氟醚之间的相互作用。尼卡地平对安氟醚麻醉犬的紧张感、心率和血压的抑制作用明显高于清醒犬。1988年，我们比较了泮库溴铵和维库溴铵在这种模式下的效果。两种药物均引起剂量依赖性正性肌力和变时效应。这些作用被认为是由交感神经末梢释放去甲肾上腺素介导的。1989年，我们在该模型中研究了地尔硫卓与七氟烷的相互作用。两种药物均可延长PQ间期，抑制发展性紧张。这些作用被观察到被其他药物增强。

In the canine isolated, blood-perfused heart preparations the direct effects of the agents which were given even into the donor dog could be observed, while in the donor animal the systemic effects of the agents which would be modified by neurohumoral compensatory reflex mechanisms could be observed.In this model, we observed the interaction between nicardipine and enflurane in 1987. Nicardipine depressed more potently developed tension, heart rate and blood pressure in enflurane anesthetized dogs than in conscious dog.In 1988, we compared the effects of pancuronium and vecuronium in this mode. Both drugs caused dose-dependent positive inotropic and chronotropic effects. These effects were suggested to be mediated by release of norepinephrine from the sympathetic nerve endings.In 1989, we investigated the interaction between diltiazem and sevo- flurane in this model. Both drugs prologed PQ interval and depressed developed tension. These effects were observed to be potentiated by each other drug.