Contingent negative variation (CNV) in tinnitus patients.

对39例主诉为耳鸣但无明显感音神经性听力损失的患者进行了关联负变(CNV)波幅检查。男性20人，女性19人，平均年龄46岁。实验对象为13名健康的医院工作人员，其中男11人，女2人，平均年龄29岁。CNV模式为：先用警告声刺激(S1：1 kHz，85dBHL)，2s后进行强制光刺激(S2：光闪光)，按下按钮停止S2-光，CNV平均20~25次。研究目的：1.研究CNV波幅与抑郁、焦虑等心理状态的关系，并采用抑郁评分和MAS评定患者后期的心理状态。1.耳鸣患者CNV波幅在早、中期显著高于对照组(p0.05)。耳鸣患者组的反应时明显长于对照组(p0.05)。4.当抑郁评分介于正常和抑郁状态之间时，只有CNV的早、中期成分波幅较低，而当抑郁评分较高时，CNV各成分的波幅均较小。这些结果表明耳鸣患者对警告刺激(S1)高度敏感，从而导致精神活动增加。

Thirty-nine patients complained of tinnitus without significant sensorineural hearing loss were examined for contingent negative variation(CNV) amplitude. Twenty were male and nineteen female and their average age was 46 y.o. Thirteen healthy hospital staff,elevev male and two female,were used for control.their average age was 29 y.o.The CNV paradigm consisted of a warning acoustic stimulus(S1:1KHz,85dBHL) followed by an imperative light stimulus(S2:light flash) 2sec later;the subject had to stop S2-light by pushing a button.CNV was averaged by 20-25 times. The relationship between CNV amplitude and psychological status such as depressive or anxiety,was studied.Later psychological status were determined by means of depressive score and MAS.1.The tinnitus patients showed a significantly large CNV amplitude than control group( p 0.05) in its early and middle components.2. Reaction time was significantly larger in tinnitus patients group than control group(p 0.05).3. Amplitude of P300 which was measured at the parietal site(Pz) was significantly smaller in tinnitus patients.4.When depressin score was in between the normal and depressive status,only early and middle components of CNV was low in its amplitude.However,all components of CNV were small,when depression scores were high. These results suggest the hypersensitivity to the warning stimulus(S1) in tinnitus patients, which leads elevated mental activity.