权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Origin of Contingent Negative Variation (CNV) and its Functional Features

偶然负变异（CNV）的起源及其功能特征

基本信息

批准号：
63570055
负责人：
GEMBA Hisae
金额：
$ 1.41万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1990
项目状态：
已结题

项目摘要

1. Nine monkeys were trained to move their hand in response to an Imperative Stimulus (I. S.) given 1 s after a Warning Stimulus (W. S.) (W. S. - I. S. task). Much shorter reaction times were observed on the W. S. - I. S. task than on the simple visuo-initiated movements. With electrodes implanted ii cerebral cortices, thereby, surface-negative, depth-positive (sーN, d-P) sustained potentials toward I. S. were recorded in the prefrontal, premotor and supplementary motor areas on both hemispheres, and s-N, d-P slowly increasing potentials were in the motor and somatosensory cortices contralateral to the hand. These potentials are considered to be composed mainly of electric dipoles due to EPSP currents generated in superficial parts of apical dendrites in pyramidal neurons in the cortical areas. They appear to correspond to CNV in the human. It is suggested that the sustained and slowly increasing potentials may be respectively related to cortical activities associated with expectation a … More nd anticipation of the I. S., and preparation for the movement like the readiness potential on the self-paced movement.2. Eight monkeys were trained to move the hand in response to I. S. given 1 s after go to W. S., but not after no-go to W. S.. S-N, d-P slow potentials (CNV) were obtained on the go W. S., whereas slow sーP, d-N potentials (CPV) were obtained in the prefrontal areas on the no-go W. S.. CPV is considered to be likely produced by electrical dipoles in the areas caused by disfacilitation of background EPSPs in the superficial parts of the apical dendrites.3. In order to learn possible contribution of cerebellar activity to CNV, cerebellar hemispherectomy ipsilateral to the operant hand was made in 3 monkeys. The slowly increasing potential in the motor cortex was entirely eliminated in all cases, whereas that in the somatosensory cortex was enhanced considerably. The result indicates the cerebellar hemisphere contributes to generation of CNV through the thalamo-motor cortex projection. Less

1.九只猴子被训练移动他们的手以回应命令刺激（I。S.）的在警告刺激（W. S.）的（W. S. - I. S.任务）。在W上观察到更短的反应时间。S. - I. S.任务比简单的视觉启动运动。通过将电极植入大脑皮质，从而使表面负性、深度正性（s-N，d-P）维持朝向I的电位。S. S-N、d-P慢增电位分别位于手对侧的运动皮层和体感皮层。这些电位被认为主要由电偶极子组成，这是由于在皮质区锥体神经元的顶树突的表面部分中产生的EPSP电流。它们似乎与人类的CNV相对应。提示持续性电位和缓慢性电位可能分别与皮层的期望活动有关， ...更多信息和预期的I。美国，和准备的运动一样，准备潜力的自主节奏的运动。八只猴子被训练移动手来回应I。S.在转到W后给定1 s。美国，但在不去W之后就不是了S..在正常条件下，测定了S-N、d-P慢电位（CNV）。美国，而在不走W上的前额区则获得慢s-EP、d-N电位（CPV）。S.. CPV可能是由顶树突浅层背景EPSP失易引起的电偶极子产生的.为了了解小脑活动对CNV的可能贡献，对3只猴进行了手术手同侧小脑半球切除术。在所有情况下，运动皮层中缓慢增加的电位被完全消除，而躯体感觉皮层中的电位则大大增强。结果表明，小脑半球通过丘脑-运动皮质投射参与CNV的形成。少