An experimental study of the effect of the orthodontic tooth movement into the bone graft area of the cleft palate patient

正畸牙移入腭裂植骨区效果的实验研究

• 批准号: 62480414
• 负责人: YAMAUCHI Kazuo
• 金额: $ 2.94万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-62480414/
• 关键词: bone graft; biodegradable tricalcium ceramic; tooth movement; biodegradable tricalcium phosphate; 矯正的歯牙移動

This study was performed to evaluate the histological changes during remodelling of autogenous PMCB(particulate marrow and cancellous bone) and TCPC(beta-tricalcium phosphate ceramic) when trans planted into the experimentary induced jaw bony defects and compared their responses to the orthod ontic force. Following results were obtained.1)Early resorption and necrosis was observed on the surface of PMCB before appositional bone formation occurred about 1-2 weeks following bone graft.On the other hand,directly appositional bone formation was observed on the surface of the Synthograft granules.lost of PMCB and Synthograft granules were remodelled by new bone formation around 8 weeks following the graft procedure.The reconstructed bony architecture of Synthograft filled area was more similar to that of the alveolar bone than the bone graft area.2)In the PMCB area root resorption and remnants of necrosed graft particles were observed where orthodontic force was applied within 5 weeks following the bone graft. However,a good biological responses to the orthodontic force were observed in the both areas after 7 weeks.3)Increased biodegradation and new bone formation were found in the Synthograft area where orthodontic force was applied.It may be the result of the applied orthodontic force.4)The regeneration of cementum and periodontal ligament was observed in the both areas.Thus,it is concluded that,PMCB seemed to be not able to response appropriately to the orthodontic force in the early bone remodelling stage,while Synthograft showed more appropriate response to the orthodontic force than PMCB.IT is suggested that TCPC is a better scaffold for bone formation where orthodontic force bearing area,and clinically very useful material as a better alternative substitute for autogenous bone.

本研究旨在观察自体骨髓和松质骨（PMCB）和β-磷酸三钙陶瓷（TCPC）移植修复颌骨缺损过程中的组织学变化，并比较它们对正畸力的反应。结果表明：1）植骨后1-2周，PMCB表面出现早期吸收和坏死，骨形成前，结果显示，移植后8周左右，PMCB和Synthograft颗粒的丢失被新骨的形成所重建，PMCB和Synthograft颗粒的重建骨结构在移植后8周左右被重建。2）在PMCB区，在植骨后5周内施加正畸力的地方，观察到牙根吸收和坏死的移植物颗粒残留。正畸力作用7周后，两区均出现了良好的生物学反应; 3）正畸力作用区的生物降解和新骨形成增加，可能是正畸力作用的结果; 4）正畸力作用区的牙骨质和牙周膜均出现了明显的再生。PMCB在骨重建早期对正畸力的反应不明显，而Synthograft对正畸力的反应明显优于PMCB，提示TCPC是一种较好的骨形成支架材料，临床上非常有用的材料，作为自体骨的更好的替代物。

项目成果

MOHAMMED, ZAKIR, HOSSAIN et al: "Biodegradable ceramic as a bone graft substitute followed by orthodontic tooth movement" J.Japan Orthod.Soc.48. 483-495 (1989)

MOHAMMED、ZAKIR、HOSSAIN 等人：“可生物降解陶瓷作为骨移植替代物，然后进行正畸牙齿移动”J.Japan Orthod.Soc.48。

モハメド・ザキ-ル・ホサイン: "Biodegradable ceramic as a bone graft substitute followed by orthodontic tooth movement" 日本矯正歯科学会雑誌. 48. 483-495 (1989)

Mohamed Zakir Hossain：“可生物降解陶瓷作为骨移植替代品，然后进行正畸牙齿移动”，日本正畸学会杂志 48. 483-495 (1989)。