An experimental study of the effect of the orthodontic tooth movement into the bone graft area of the cleft palate patient

点击翻译按钮获取中文摘要

This study was performed to evaluate the histological changes during remodelling of autogenous PMCB(particulate marrow and cancellous bone) and TCPC(beta-tricalcium phosphate ceramic) when trans planted into the experimentary induced jaw bony defects and compared their responses to the orthod ontic force. Following results were obtained.1)Early resorption and necrosis was observed on the surface of PMCB before appositional bone formation occurred about 1-2 weeks following bone graft.On the other hand,directly appositional bone formation was observed on the surface of the Synthograft granules.lost of PMCB and Synthograft granules were remodelled by new bone formation around 8 weeks following the graft procedure.The reconstructed bony architecture of Synthograft filled area was more similar to that of the alveolar bone than the bone graft area.2)In the PMCB area root resorption and remnants of necrosed graft particles were observed where orthodontic force was applied within 5 weeks following the bone graft. However,a good biological responses to the orthodontic force were observed in the both areas after 7 weeks.3)Increased biodegradation and new bone formation were found in the Synthograft area where orthodontic force was applied.It may be the result of the applied orthodontic force.4)The regeneration of cementum and periodontal ligament was observed in the both areas.Thus,it is concluded that,PMCB seemed to be not able to response appropriately to the orthodontic force in the early bone remodelling stage,while Synthograft showed more appropriate response to the orthodontic force than PMCB.IT is suggested that TCPC is a better scaffold for bone formation where orthodontic force bearing area,and clinically very useful material as a better alternative substitute for autogenous bone.