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Functional Morphology of the Feto-Placental Unit in Domestic Animals.

家畜胎儿胎盘单位的功能形态学。

基本信息

批准号：
63480091
负责人：
YAMAUCHI Shoji
金额：
$ 4.16万
依托单位：
Osaka Prefecture University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1990
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-63480091/
关键词：
Fetoーplacental unit Fetal endocrine glands Morphology of placenta Endocrine activity of placenta Maintenance of pregnancy 胎子-胎盤系胎盤内分泌機能

项目摘要

1. Macroscopical and scanning electron microscopical investigations on a placental vasular architecture by means of the resin injection were undertaken. General vascular architectures, chronological changes during pregnancy and species differences due to the placental types were clarified in fetal placenta of the cow, maternal and fetal placentae of the bitch and maternal placenta of the suncus.2. In addition to the microscopical and electron microscopical study on the histogenesis of the porcine fetal hypophysis, an enzyme immunological investigation by means of antibodies for ACTH, GH, LH, and PRL was also undertaken. Stages of an appearance of each gland cell in the anterior pituitary gland were clarified. Furthermore, the characteristics of the distribution pattern of each gland cell during the fetal life were also clarified.3. Zonation and the endocrine activity of the fetal porcine adrenal gland were clarified by means of the histometry as well as the investigation on activities for hydroxysteroid dehydrogenase (HSD). In an early fetal stage, the adrenal gland was mainly consisted from cells of the fetal cortex. In a latter half of pregnancy, a definitive cortex particularly the zona fasciculate developed progressively. Meanwhile, the fetal cortex involuted gradually. Both the fetal cortex and the zona fasciculata showed the similar activities for HSD, hence the important role relating to a feto-placental unit was suspected.4. Histometry, a detection for HSD activities and an electron microscopical investigations were undertaken on a histogenesis of the fetal cat adrenal gland. In a case of the cat, cells of the fetal cortex did not show a sign of involution even in a late stage of pregnancy. Instead, the fetal cortex as seemed to be incorporated into the zona reticularis. Accordingly, the fetal cortex seemed to play a role up to the middle of pregnancy and the zona fasciculata succeeds thereafter.

1.通过树脂注射对胎盘血管结构进行了宏观和扫描电子显微镜研究。通过对奶牛胎儿胎盘、母犬母胎胎盘和太阳鱼母胎盘的研究，阐明了奶牛胎儿胎盘、母犬母胎胎盘和太阳鱼母胎盘的血管构筑、妊娠期的时间变化以及胎盘类型的种属差异.除了对猪胎儿垂体的组织发生进行显微镜和电子显微镜研究外，还用ACTH、GH、LH和PRL抗体进行了酶免疫学研究。阐明了垂体前叶中每个腺细胞出现的阶段。进一步阐明了各腺细胞在胎儿期的分布特点.通过组织学测量和羟类固醇脱氢酶（HSD）活性的测定，阐明了胎猪肾上腺的分区和内分泌活动。在胎儿早期，肾上腺主要由胎儿皮质细胞组成。在怀孕的后半期，一个明确的皮质，特别是束状皮质，逐步发展。胎儿皮质逐渐退化。胎儿皮质和束状核对HSD的活性相似，因此推测其可能与胎儿胎盘单位有关.本文对胎猫肾上腺的组织发生进行了组织计量学、HSD活性检测和电镜观察。在一个猫的案例中，胎儿皮质的细胞甚至在怀孕后期也没有显示出退化的迹象。相反，胎儿的皮质似乎被并入网状纤维。因此，胎儿皮质似乎发挥了作用，直到怀孕中期和束状体成功之后。