权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Study for high-dose-rate interstitial radiation therapy using remote after-loading technique

利用远程后装技术进行高剂量率间质放射治疗的研究

基本信息

批准号：
63480251
负责人：
MASAKI Norie
金额：
$ 3.39万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1989
项目状态：
已结题

项目摘要

Interstitial radiation therapy has played an important role in the management of cancer treatment for head and neck cancer, especially for cancer in the oral cavity. Disadvantages by this conventional interstitial therapy is weighted against the hospitalization of the patients and possible risks due to the radiation exposure to the medical staff. The use of high dose-rate after-loading techniques using Ir-192 has assured this procedure without personal exposure to ionizing radiation during the implantation, and without hospitalization of the patients.By this remote after-loading technique, the rigid guide needles or applicators (non-radioactive) are introduced first and subsequently inserting the Ir-192 afterloading sources. Several new applicators for use in the oral cavity has been developed. The dose distribution when using these applicators for single plane implant and/or for double plane implants are studied.Optimum delivery dose by this high dose-rate interstitial therapy should be different from conventional low dose-rate interstitial radiation therapy, with possible dose effect factor 1.5-2.0, although more clinical experience is needed.

间质放射治疗在头颈癌，特别是口腔癌的治疗管理中发挥了重要作用。这种传统间质疗法的缺点与患者住院治疗以及医务人员暴露于辐射可能带来的风险相权衡。使用 Ir-192 的高剂量率后装技术确保了该手术在植入过程中个人不会暴露于电离辐射，也无需患者住院。通过这种远程后装技术，首先引入刚性导针或施药器（非放射性），然后插入 Ir-192 后装源。已经开发出几种用于口腔的新型涂抹器。研究了使用这些施源器进行单平面植入和/或双平面植入时的剂量分布。这种高剂量率间质治疗的最佳输送剂量应不同于传统的低剂量率间质放射治疗，剂量效应因子可能为1.5-2.0，尽管需要更多的临床经验。