Echocardiography System for Laboratory Rodents

实验室啮齿动物超声心动图系统

• 批准号: 438137577
• 金额: --
• 依托单位: Rheinisch-Westfälische Technische Hochschule Aachen
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2020
• 资助国家: 德国
• 起止时间: 2019-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/438137577?language=en
• 关键词: Echocardiography; System; Laboratory; Rodents

Ongoing cardiovascular research initiatives and collaborative projects are analyzing animal models for uremic cardiomyopathy and heart failure as well as myocardial infarction and vascular calcification. Our recently initiated consortium has the core focus to understand cardiovascular pathophysiology in chronic kidney disease including vascular and cardiac remodeling. Given the growing demand on in vivo measurements of cardiac function within the initiative but also at various other research projects a novel state of the are ultrasound device that allows high-resolution imaging of the heart as well as the vasculature and includes color-duplex mode and speckle tracking software to detect minor changes in cardiac contractility, as typically occurring in chronic kidney disease, is urgently needed. However, at University Hospital Aachen, the currently available system is off the market since 2013 and not anymore considered state of the art due to its low resolution and missing color duplex sonography. Therefore, a state of the art ultra high frequency ultrasound system is urgently needed to analyze cardiac and vascular function in the above mentioned projects. The integrated speckle tracking application, the color doppler and the new 3D to 4D mode of the system applied for additionally will enable state of the art evaluation of cardiovascular parameters needed by all project partners. With the support of a high resolution ultrasound, we aim to develop therapies against early uremic cardiac and vascular changes.

正在进行的心血管研究活动和合作项目正在分析尿毒症心肌病和心力衰竭以及心肌梗死和血管钙化的动物模型。我们最近发起的联盟的核心重点是了解慢性肾脏疾病的心血管病理生理学，包括血管和心脏重构。鉴于该倡议以及其他各种研究项目对在体测量心脏功能的需求日益增长，迫切需要一种新型的心脏超声设备，该设备允许对心脏和血管系统进行高分辨率成像，并包括彩色双工模式和斑点跟踪软件，以检测心脏收缩能力的微小变化，如通常发生在慢性肾脏疾病中。然而，在亚琛大学医院，目前可用的系统自2013年起就退出了市场，由于其低分辨率和缺少彩色双工超声，不再被视为最先进的系统。因此，在上述项目中迫切需要一种最先进的超高频超声系统来分析心脏和血管功能。此外，该系统的集成斑点跟踪应用程序、彩色多普勒和新的3D到4D模式将使所有项目合作伙伴所需的心血管参数能够进行最先进的评估。在高分辨率超声的支持下，我们的目标是开发针对早期尿毒症心脏和血管变化的治疗方法。