Epioural Anesthesthesia Using Inhalational Agents

我们研究了一种使用吸入剂进行硬膜外麻醉的可能性。在猫中，进行椎板切除术并将微电极插入脊髓后锥体。从第5层细胞的单个细胞单位记录活动。研究了疼痛刺激引起的自发活动和电位。脊髓暴露于高浓度的各种吸入剂中。研究了其对细胞活性的影响。通过这种途径给药的吸入性药物对细胞活性没有明显的抑制作用。偶尔，他们刺激自发的活动。我们未能证明直接施用于脊髓表面的吸入剂能持续抑制这些细胞的活性。我们使用了氟烷和二乙醚的蒸气。他们显著减少了局部麻醉剂的需求。效力没有我们原先假设的那么高。麻醉诱导的速度较慢。我们能检测出过期气体中的药剂，但无法定量测定其含量。我们用计算机模型分析了经此途径给药的吸入性药物的药代动力学。给身体的药物需要量应少于常规吸入麻醉的1%。我们发表了几篇与这项研究相关的文章和书籍。

We investigated a possibility of epidural anesthesia using inhalational agents by a combination of following methods.1. In cats, a laminectomy was performed and a microelectrode was inserted into the posterior cone of the spinal cord. Activity is recorded from a single cell unit from lamina 5 cells. Both spontaneous activities and potentials evoked from pain stimuli were studied.The spinal cord was exposed to a high concentration of various inhalational agents. Effects on cell activities were studied.Inhalational agents administed via this route did not clearly suppress the cell activity. Occasionally, they stimulated the spontaneous activities.We failed to prove that inhalational agents administed directly on the surface of the spinal cord consistently suppress the activity of these cells.2. We administered vapor of both halothane and diethylether. They, decreased significantly the requirement of local anesthetics. The potency is not quite as high as we originally hypothesized. The speed with which the anesthesia is induced was slow.3. We could detect the agents in the expired gases, but failed to determine the amount quantitatively.4. We analyzed the pharmacokinetics of inhalational agents given by this route using a computer model. The requirement of agents to the body should be less than 1% of what we generally use for regular inhalational anesthesia.5. We published several articles and books in relation to this study.