Anaylsis of aging process of blood vessels by measuring pulse wave propagation

该项目产生了各种新技术和发现，设计了一些方法，并取得了以下重要成果。1)测量病变血管置换前后沿主动脉脉波传播情况。我们发现脉冲波沿人造血管的传播速度比沿原始血管的传播速度快得多。2)我们设计了一种简单的测量PWV（脉搏波速度）的方法，比较了心电图r波起爆与手指脉搏增厚仪起爆的差异。3)我们在各种实验方案中验证了它的有效性。我们发现，根据不同的情况，个人在同一地方的PWV可能会有所不同。直到最近，在分析PWV时，管壁厚度一直被忽略。我们假设壁厚在决定压水电压中起着至关重要的作用。我们从理论上分析了这一因素，并证明了这一因素在确定脉冲电压值方面是非常重要的。证明了壁厚和壁质量是不可忽视的。6)众所周知，PWV分析偶尔会产生意想不到的、错误的结果，因此脉冲波通常沿着其他方法证实的硬化血管传播很慢。我们得出的结论是，硬化血管通常变得又厚又重，同时变得刚性和不那么柔顺，从而相互抵消了对PWV的影响。

This project yielded various new techniques and findings, devising a few methodologies and achieving the following important results.1) We measured pulse wave propagation along the aorta before and after the replacement of diseased vessel by artificial synthetic vessel. We found that pulse wave propagates considerably more fast along the artificial vessel made of synthetic material than along the original vessels.2) We devised a simple method of measuring PWV (pulse wave velocity), comparing the initiation of R-wave of EKG with the initiation of finger pulse plethismograph.3) We verified its usefulness in various experimental protocols. We found PWV may vary in the same place of a single individual, depending upon the different circumstances.Thickness of the vessel walls has been ignored in analyzing PWV until recently. We hypothesized that the wall thickness plays a crucial role in determining the PWV.We analyzed this theoretically, and proved this factor is quite important in determining the PWV.5) We analyzed the pulse wave propagation in various models. We proved that the wall thickness and the wall mass should not be ignored.6) PWV analysis is known to yield occasionally unexpected, faulty results so that pulse wave often travels quite slowly along sclerotic vessels proven in other methods. We conclude that sclerotic vessels often become thick and heavy as well as rigid and less compliant, thereby cancelling the effects on PWV each other.