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Anaylsis of aging process of blood vessels by measuring pulse wave propagation

通过测量脉搏波传播分析血管老化过程

基本信息

批准号：
10671444
负责人：
SUWA Kunio
金额：
$ 1.92万
依托单位：
Teikyo University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671444/
关键词：
Pulse wave propagation Pulse wave velocity artificial vessel R-wave of EKG Pulse oximeter thickness of vessel wall Arteriosclerosis Diagnosis of Arteriosclerosis 脈波伝播動特性大動脈波伝播速度脈波伝播時間心電図パルスオキシメトリー回路シミュレーションコンピュータシミュレーション

项目摘要

This project yielded various new techniques and findings, devising a few methodologies and achieving the following important results.1) We measured pulse wave propagation along the aorta before and after the replacement of diseased vessel by artificial synthetic vessel. We found that pulse wave propagates considerably more fast along the artificial vessel made of synthetic material than along the original vessels.2) We devised a simple method of measuring PWV (pulse wave velocity), comparing the initiation of R-wave of EKG with the initiation of finger pulse plethismograph.3) We verified its usefulness in various experimental protocols. We found PWV may vary in the same place of a single individual, depending upon the different circumstances.Thickness of the vessel walls has been ignored in analyzing PWV until recently. We hypothesized that the wall thickness plays a crucial role in determining the PWV.We analyzed this theoretically, and proved this factor is quite important in determining the PWV.5) We analyzed the pulse wave propagation in various models. We proved that the wall thickness and the wall mass should not be ignored.6) PWV analysis is known to yield occasionally unexpected, faulty results so that pulse wave often travels quite slowly along sclerotic vessels proven in other methods. We conclude that sclerotic vessels often become thick and heavy as well as rigid and less compliant, thereby cancelling the effects on PWV each other.

本研究取得了多项新技术和新发现，设计了几种方法，并取得了以下重要成果：1）测量了人工合成血管置换病变血管前后脉搏波沿主动脉的传播沿着。我们发现脉搏波在人造血管中的传播速度比沿着原血管中的传播速度快得多。2）我们设计了一种简单的测量脉搏波速度的方法，并将心电图R波的起始与手指脉搏体积描记器的起始进行了比较。我们发现PWV在同一个人的同一个部位可能会因不同的情况而有所不同，而血管壁的厚度在PWV的分析中一直被忽略。我们假设壁厚在决定PWV中起着至关重要的作用，我们从理论上对此进行了分析，并证明了这个因素在决定PWV中是相当重要的。5）我们分析了各种模型中的脉搏波传播。我们证明了壁厚和壁质量不应被忽略。6）PWV分析已知偶尔会产生意外的错误结果，因此脉搏波通常沿沿着血管传播，这在其他方法中得到了证明。我们的结论是，scaffold血管往往变得厚和重以及刚性和较低的顺应性，从而抵消对PWV的影响。