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Experimental Study on Hearing Impairment in Acoustic Neuromas

听神经瘤听力障碍的实验研究

基本信息

批准号：
63480385
负责人：
KANZAKI Jin
金额：
$ 3.58万
依托单位：
Keio University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1990
项目状态：
已结题

项目摘要

The relationship between cochlear blood flow (CBF) and cochlear electrical activity was investigated to better understand cochlear circulatory insufficiency, which is considered to be a cause of hearing loss acoustic neuroma.1. Experimental animal models for cochlear circulatory insufficiencyExperimental animal models for cochlear circulatory insufficiency were made by asphyxia, NO2 anoxia and obstruction of AICA.Changes in systemic blood pressure (BP) during asphyxia and NO2 anoxia were clearly associated with changes in CBF. At the initial stage of asphyxia, however, CBF did not change in spite of the decrease in BP. These discrepancies appeared to be related to autoregulation of CBF. There was no difference in the change in compound action potential of the eighth nerve (AP) between asphyxia and NO2 anoxia.Data from the experiment using AICA obstruction were insufficient to provide information on changes in AP as CBF decreased. However, the data indicated that the higher the CBF reduction rate, the higher the disappearing rate of AP.2. Effects of steroid hormone and hypothermia on cochlear circulatory insufficiencyAlthough changes in CBF following systemic administration of steroid hormone were not clearly observed, the recovery time of N1 (AP) latency became shorter with systemic administration of steroid hormone. Similar results were obtained with hypothermia. Based on the analysis of these results, we concluded that the reversibility of the cochlear activity in cochlear circulatory insufficiency could be improved by the administration of steroid and hypothermia.

研究耳蜗血流量（CBF）与耳蜗电活动之间的关系，以更好地了解耳蜗循环不足，耳蜗循环不足被认为是听力损失听神经瘤的原因。1．耳蜗循环功能不全的实验动物模型采用窒息、NO2缺氧和AICA阻塞的方法制作耳蜗循环功能不全的实验动物模型。窒息和NO2缺氧时全身血压(BP)的变化与CBF的变化明显相关。然而，在窒息初期，尽管血压下降，CBF却没有变化。这些差异似乎与 CBF 的自动调节有关。窒息和 NO2 缺氧之间第八神经 (AP) 复合动作电位的变化没有差异。使用 AICA 阻塞的实验数据不足以提供随着 CBF 降低而出现的 AP 变化的信息。然而，数据表明CBF降低率越高，AP.2的消失率越高。类固醇激素和低温对耳蜗循环功能不全的影响虽然没有清楚地观察到全身施用类固醇激素后CBF的变化，但随着全身施用类固醇激素，N1（AP）潜伏期的恢复时间变短。低温治疗也获得了类似的结果。基于对这些结果的分析，我们得出结论，通过类固醇和低温治疗可以改善耳蜗循环功能不全时耳蜗活动的可逆性。