Improving the Matteson Homologation for Natural Product Syntheses

改进天然产物合成的 Matteson 同源性

• 批准号: 439145210
• 负责人: Professor Dr. Uli Kazmaier
• 金额: --
• 依托单位: Institut für Organische Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/439145210?language=en
• 关键词: Improving; Matteson; Homologation; Natural; Product

The goal of this project is to develop the Matteson Homologation as a general tool for the stereoselective synthesis of natural products. The existing tool box should be expanded by using functionalized building blocks, giving access to a range of different classes of natural products (amino acids, peptides, polyketides, macrolides, …). The new developed protocols will directly be applied in total syntheses to evaluate and demonstrate their scope and limitations.

该项目的目标是开发Matteson同系物作为天然产物立体选择性合成的通用工具。现有的工具箱应该通过使用功能化的构建块来扩展，允许访问一系列不同类别的天然产品(氨基酸、多肽、聚酮、大环内酯类、…)。新开发的方案将直接应用于全合成，以评估和证明其范围和局限性。