Twin screw extruder

在布伦瑞克工业大学制药工程中心（PVZ），来自机械工程和生命科学学院的科学家，特别是来自过程工程、制药以及微观和生产技术领域的科学家，在跨学科的联合研究项目中工作。该中心的目标是通过整合参与学科的专业知识，开发和表征有效的配方策略以及具有挑战性的活性药物成分的制造和加工方法。特别注意那些难以加工的活性物质，如溶解度差或生物分子结构敏感的活性物质。关于未来的重要问题，我们感兴趣的主要议题还包括个体化药物的持续生产和发展。随着挤出机的应用，它旨在为这些研究目标在PVZ建立一个中心技术。除其他外，该装置将用于开发新型、挤压和颗粒为基础的剂型，特别是用于有效和个体化治疗。在这种情况下，对挤压和造粒以及下游操作的过程-结构-性能关系的深刻理解将得到发展。这包括对过程和产品监控方法的研究，以便合理地定义可推导的过程限制和过程质量相关性，以及开发模拟方法以阐明潜在的微过程。

At the Center of Pharmaceutical Engineering (PVZ) at TU Braunschweig, scientists from the Faculties of Mechanical Engineering and Life Sciences, in particular from the fields of process engineering, pharmacy as well as micro and production technology, work interdisciplinary on joint research projects. The aim of the center is to develop and characterize efficient formulation strategies as well as manufacturing and processing methods for challenging active pharmaceutical ingredients by bundling the expertise from the participating disciplines. Special attention is paid to active substances with difficult processing properties such as those with poor solubility or sensitive biomolecular structure. With regard to important future issues, major topics of interest also include continuous production and the development of individualized medicines. With the extruder applied for, it is intended to establish a central technology at the PVZ for these research objectives. The device is to be used, among others, for the development of novel, extrusion- and granulation-based dosage forms, in particular for efficient and individualized therapy. In this context, a deep understanding of process-structure-property relationships in extrusion and granulation as well as in downstream operations is going to be developed. This involves research on methods for process and product monitoring in order to define rationally derivable process limits and process-quality-correlations as well as the development of simulation methods for the elucidation of underlying microprocesses.