High Throughput Electrochemical Workstation System for Organic Electrocatalysis and In-Operando Reaction Control

近年来，有机电催化经历了令人瞩目的复兴，成为一种革命性的工具，使分子合成发生了革命性的变化。要通过金属电催化实现可持续的直接功能化，获得最先进的高通量电化学仪器是至关重要的。设想的项目包括：i)电化学肽的后期多样化，ii)电化学聚合物的升级，iii)计算研究的验证，iv)3D金属络合物的电催化，v)不对称电催化，所有这些都需要对所有反应参数进行有效的优化。到目前为止，已发表的程序主要局限于恒电流电解，而由于哥廷根大学缺乏所需的仪器，在恒电位条件下的电催化是不可行的。这一关键限制阻碍了高化学选择性和氧化还原敏感催化剂等。电催化高通量仪器实现了有效的恒电位歧管。选择在所需的氧化还原转化所需的最低水平的氧化电位，进一步使电化学成为实现独特水平的化学选择性的理想手段。与电合成形成鲜明对比的是，电化学和金属催化的结合需要处理和表征高灵敏的过渡金属物种。因此，对高活性中间体的鉴定和表征，操作中反应控制是必不可少的。

In recent years, organic electrocatalysis has undergone a remarkable renaissance, thus emerging as a transformative tool that revolutionizes molecular syntheses. To enable sustainable direct functionalizations by metallaelectro-catalysis it is of utmost importance to have access to a state of the art electrochemical high-throughput instrumentaion. The envisioned project features i) electrochemical peptide late-stage diversification, ii) electrochemical polymer upgrading, iii) validation of computational studies, iv) electrocatalysis with 3d metal complexes, and v) asymmetric electrocatalysis, all of which require effective optimization of all reaction parameters. Thus far, published procedures are predominantly restricted to galvanostatic electrolysis, while electrocatalysis under a potentiostatic regime is not viable due to a lack of the requested instrument at the Göttingen University. This key limitation prevents among others high chemo-selectivity and redox-sensitive catalysts. The Electrocatalysis High-Throughput Instrument enables effective potentiostatic manifolds. The option to dial in oxidizing potential at the minimum level required for the desired redox transformation further renders electrochemistry an ideal means to achieve unique levels of chemoselectivity. The merger of electrochemistry and metal catalysis, in stark contrast to electrosynthesis, requires the handling and characterization of highly sensitive transient transition metal species. Thus, in-operando reaction control is essential for the identification and characterization of highly reactive intermediates.