High Throughput Electrochemical Workstation System for Organic Electrocatalysis and In-Operando Reaction Control

用于有机电催化和操作中反应控制的高通量电化学工作站系统

• 批准号: 440844843
• 金额: --
• 依托单位: Georg-August-Universität Göttingen
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2020
• 资助国家: 德国
• 起止时间: 2019-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/440844843?language=en
• 关键词: Throughput; Electrochemical; Workstation; System; Organic

In recent years, organic electrocatalysis has undergone a remarkable renaissance, thus emerging as a transformative tool that revolutionizes molecular syntheses. To enable sustainable direct functionalizations by metallaelectro-catalysis it is of utmost importance to have access to a state of the art electrochemical high-throughput instrumentaion. The envisioned project features i) electrochemical peptide late-stage diversification, ii) electrochemical polymer upgrading, iii) validation of computational studies, iv) electrocatalysis with 3d metal complexes, and v) asymmetric electrocatalysis, all of which require effective optimization of all reaction parameters. Thus far, published procedures are predominantly restricted to galvanostatic electrolysis, while electrocatalysis under a potentiostatic regime is not viable due to a lack of the requested instrument at the Göttingen University. This key limitation prevents among others high chemo-selectivity and redox-sensitive catalysts. The Electrocatalysis High-Throughput Instrument enables effective potentiostatic manifolds. The option to dial in oxidizing potential at the minimum level required for the desired redox transformation further renders electrochemistry an ideal means to achieve unique levels of chemoselectivity. The merger of electrochemistry and metal catalysis, in stark contrast to electrosynthesis, requires the handling and characterization of highly sensitive transient transition metal species. Thus, in-operando reaction control is essential for the identification and characterization of highly reactive intermediates.

近年来，有机电催化经历了一个显着的复兴，从而成为一种革命性的工具，彻底改变分子合成。为了通过金属电催化实现可持续的直接功能化，获得最先进的电化学高通量仪器是至关重要的。设想的项目包括i)电化学肽后期多样化，ii)电化学聚合物升级，iii)计算研究验证，iv)三维金属配合物电催化，v)不对称电催化，所有这些都需要有效优化所有反应参数。到目前为止，已发表的程序主要局限于恒流电解，而由于Göttingen大学缺乏所需的仪器，在恒电位制度下的电催化是不可行的。这一关键限制阻碍了高化学选择性和氧化还原敏感催化剂的开发。电催化高通量仪器使有效的恒电位歧管。将氧化电位调到所需氧化还原转化所需的最低水平的选择进一步使电化学成为实现独特化学选择性水平的理想手段。电化学和金属催化的合并，与电合成形成鲜明对比，需要处理和表征高度敏感的瞬态过渡金属物种。因此，在操作中反应控制是鉴定和表征高活性中间体的必要条件。