The assessment of liver functional reserve by the measurement of the amino acids utility rate and hepatic protein synthesis rate.
通过测定氨基酸利用率和肝蛋白合成率来评估肝储备功能。
基本信息
- 批准号:03807083
- 负责人:
- 金额:$ 1.15万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (C)
- 财政年份:1991
- 资助国家:日本
- 起止时间:1991 至 1992
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In order to asses the liver functional reserve, we investigated clinical and experimental hepatic resection cases using the procedure of 1) hepatic amino acids utility index and 2) hepatic protein synthesis rate of needle biopsied liver specimens preoperatively and compared with their post operative liver function. The amino acids utility index statistically correlated well with the degree of hepatic disorders in both experimental and clinical liver cirrhosis through pre and post operative period. And this index meant the whole liver protein synthetic activity. On the contrary, the hepatic protein synthesis rate of needle biopsied liver (HPS) represented the function of a unit of liver tissue. In the experimental liver cirrhosis and clinical liver cirrhosis cases, this HPS were already accelerated at the unit of liver but not in whole liver function. The acceleration of the HPS at the unit of the liver theoretically have the limitation, the degree of the acceleration of HPS, therefore, meant the decreasing of their functional reserve.Measuring of the amino acid utility index could bring real time assessment of the liver function, and the HPS showed the functional reserve of the liver. By these data, we might preoperatively decide the hepatic resection mass for the satisfactory post operative liver function.
为了评估肝功能储备,我们采用术前肝穿刺标本的肝氨基酸利用指数和肝蛋白合成率,并与术后肝功能进行比较,对临床和实验肝切除术病例进行调查。氨基酸效用指数与实验性和临床肝硬化术前、术后肝功能紊乱程度均有较好的统计学相关性。该指标表示全肝蛋白合成活性。相反,针活检肝脏(HPS)的肝蛋白合成率代表了一个单位肝组织的功能。在实验性肝硬化和临床肝硬化病例中,这种HPS已经在肝脏单位加速,但在整个肝功能中没有加速。肝单位HPS的加速在理论上是有局限性的,因此HPS加速的程度就意味着其功能储备的减少。氨基酸效用指数的测定可以实时评价肝脏功能,HPS反映肝脏的功能储备。根据这些资料,我们可以在术前确定肝切除肿块,以获得满意的术后肝功能。
项目成果
期刊论文数量(36)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Asano T, Kainuma O Kubota T, Nakagouri T, Enomoto K, Tokoro Y, Matsui Y, Jingu K, Maruyama M, Miyauchi H, Nagashima T, Kobayashi S, Kikuchi T and Isono K: "The assessment of liver functional reserve by MEGX test and hepatic protein synthesis measuring" Th
Asano T、Kainuma O Kubota T、Nakagouri T、Enomoto K、Tokoro Y、Matsui Y、Jingu K、Maruyama M、Miyauchi H、Nagashima T、Kobayashi S、Kikuchi T 和 Isono K:“通过 MEGX 评估肝功能储备
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- 影响因子:0
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Kainuma O, Asano T, Enomoto K, Kubota T and Isono K: "Measuring of the lidocaine metabolite, monoethylglycinexylidide, as a liver functional test for cirrhosis and obstructive jaundice." Japanese J of the gastroenterological surgical society. 24(9). 2354-
Kainuma O、Asano T、Enomoto K、Kubota T 和 Isono K:“测量利多卡因代谢物单乙基甘氨酸,作为肝硬化和阻塞性黄疸的肝功能测试。”
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- 影响因子:0
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甲郡 聡夫: "針生検による肝蛋白合成率(HPS)測定と肝機能予備力評価への応用" 日本消化器病学会雑誌. 88(8). 1566-1570 (1991)
Satoshi Kougori:“通过针活检测量肝脏蛋白质合成率(HPS)及其在肝功能储备评估中的应用”,日本胃肠病学会杂志 88(8)(1991)。
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- 影响因子:0
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中郡 聡夫,浅野 武秀,他: "針生検法による肝蛋白合成率(HPS)測定と肝機能予備力評価への応用" 日本消化器病学会雑誌. 88. 1566-1570 (1991)
Satoshi Nakagori、Takehide Asano 等人:“针活检法测量肝脏蛋白质合成率 (HPS) 及其在肝功能储备评估中的应用”日本胃肠病学会杂志 88. 1566-1570 (1991)。
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- 影响因子:0
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Toru KUBOTA: "Hepatic protein symthesis rate of biopsied tissue in the ossessment of preservation Solution" Transplantation Proceedingo. 24(4). 1625-1627 (1992)
Toru KUBOTA:“保存液中活检组织的肝蛋白合成率”移植论文集。
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ASANO Takehide其他文献
ASANO Takehide的其他文献
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{{ truncateString('ASANO Takehide', 18)}}的其他基金
Cancer stem cell analysis of pancreas duct cell carcinoma a fundamental study for new strategy against pancreatic cancer
胰腺导管细胞癌的癌症干细胞分析是抗胰腺癌新策略的基础研究
- 批准号:
17591453 - 财政年份:2005
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Thermal Ablation and Free Radicals induction by Focused Ultrasound as tool for Cancer Therapy
聚焦超声热消融和自由基诱导作为癌症治疗工具
- 批准号:
08407029 - 财政年份:1996
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
A Study of Farnesyltransferase Inhibitor for the Treatment of Pancreatic Cancer.
法呢基转移酶抑制剂治疗胰腺癌的研究。
- 批准号:
07671290 - 财政年份:1995
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A study of real time liver function assay -Amino acid utility index and protein synthetic rate-
实时肝功能测定研究-氨基酸效用指数和蛋白质合成率-
- 批准号:
01570737 - 财政年份:1989
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)