权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Effects of algal polysaccharide in curing and preventing of cardiovascular disease

海藻多糖治疗和预防心血管疾病的作用

基本信息

批准号：
04660223
负责人：
NODA Hiroyuki
金额：
$ 1.41万
依托单位：
Mie University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1994
项目状态：
已结题

项目摘要

Thirteen species among 26 species of seaweeds, some of which are commonly used as food, showed antihypertensive effect and decreased the levels of total cholesterol (TC), free cholesterol (FC), triglyceride (TG), and low density lipoprotein cholesterol (LDL). In addition , the serum level of high density lipoprotein cholesterol (HDL) was elevated 46.0% by the seaweed powder diets. Six polysaccharides derived from several active seaweed species were examined, and funoran was found to have appreciable suppression of hypertention and hypercholesterolemia.The funaran isolated from Gloipeltis tenax consisted mainly of galactose, 3,6-anhydro-galactose sulfate polysaccharide. It had an average molecular weight of 90,500. The effects of funoran to lower blood pressure and cholesterol was examined the rats fed a saline solution and cholesterol-containing diet. Funoran caused significant reduction of systolic blood pressure. At the same time, the increase of sodium, water excretion and sodium potassium ratio in urine in the funaran group was more significant in the experimental rats than in the control group. Moreover, the ratio of Na^+ and K^+ in serum was decreased by the funoran diet. Thus, the enhanced ability of funoran to excrete sodium in urine may be an important factor for decreasing the blood pressure. The funoran decreased the serum TC,FC,TG,and LDL levels, and atherogenic index in the rats. The cholesterol level in feces was increased by the funoran diet. Thses finding indicate that the antihyperlipidemic effect of funoran may be caused the enhanced excretion of cholesterol into faces.

在26种海藻中，有13种海藻具有抗高血压作用，能降低总胆固醇（TC）、游离胆固醇（FC）、甘油三酯（TG）和低密度脂蛋白胆固醇（LDL）水平。此外，高密度脂蛋白胆固醇（HDL）水平提高46.0%的海藻粉饲料。从几种活性海藻中提取的六种多糖，发现福莫兰具有明显的降血压和降胆固醇作用，从海萝中分离的福莫兰主要由半乳糖、3，6-脱水半乳糖硫酸酯多糖组成。它的平均分子量为90，500。在给大鼠喂食生理盐水和含胆固醇的饮食的情况下，检查了福诺然降低血压和胆固醇的效果。Funoran引起收缩压显著降低。与此同时，富马酸组大鼠尿钠、水排出量和尿钠钾比值的增加均较对照组显著。此外，血清中Na^+和K^+的比例降低，由funoran饮食。因此，氟诺仑提高尿钠排泄能力可能是降低血压的重要因素。氟诺能降低大鼠血清TC、FC、TG、LDL水平及动脉粥样硬化指数。粪便中的胆固醇水平增加的funoran饮食。提示福诺然的降血脂作用可能与其促进胆固醇向面部的排泄有关。