Studies on the antitumor activity of seaweed and phytoplankton

1. 海藻和浮游植物的抗肿瘤活性。57种海藻和植藻粉经口服后，对感染埃利希氏汽车癌小鼠的抑制率最高，为69.8%，其次为黑藻（60.0%）、海带（57.6%）、紫斑卟啉（53.2%）和真丝藻（52.1%）。甲氧甲胺素A纤维肉瘤小鼠经腹腔注射后，抑制率最高的是马尾藻（55.5%），其次是棉衣藻（39.8%）、金曲藻（39.1%）、羊尾藻（36.6%）和Ecklonia cai（35.9%）。人细胞培养细胞毒性研究海藻和浮游植物中抗肿瘤物质。从57种海藻和浮游植物中提取了77个多糖、水溶性高分子量组分、水溶性低分子量组分和单宁样物质。通过对人肿瘤细胞WI-38 VA-13的生长抑制率考察了这些样品的抗肿瘤作用(1)。多糖。绿藻单胞杂多糖具有较强的活性，IC_<50>=18.6马克杯/毫升(2)。水溶性高分子量分数。抑癌剂对肿瘤生长有抑制作用（IC_<50>=41.6 mug/ml）。水溶性低分子量组分。11种有效菌中，抑制率最高的是abietina Hetezrochordaria （IC_<50>=2.7 mug/ml）。Tannin-like物质。瘤状葡萄藤具有较高的抑制率（IC_<50>=10.1 mug/Ml）。

1. Antitumor activity of seaweed and phytoplankton.(1). After the preoral administration of powdered 57 species of seaweed and phyioplanlcton to mice inoculated wit)i Ehrlich car cinoma, Scytosiplion lomentaria showed the highest inhibition rate (69.8%), followed by Lessonia nigrescens (60.0%), Laminaria japonica (57.6%), Porphyra Xezoensis (53.2%) and Euchetima ,&,elatinae (52.1%).(2.). After the intraperitoneal administration to mice inoculated with Meth A fibrosarcoma, the inhibition rate were highest in Sargasstim patens (55.5%), followed by Etichetima cottonoii (39.8%), S. ringgoldianum (39.1%), L. atigiistats (36.6%) and Ecklonia cai,a (35.9%).2. Investigation of antitumor substances in seaweed and phytoplankton by cytotoxicity in human cell cultures.Seventy seven samples of polysaccharides, water-soluble high iixolecxilar weight fraction, water-soluble low molecular weight fraction and tannin-like substances were extracted from fifty seven species of seaweed and phytoplankton. Antitumor effect of these samples were investigated by growth inhibition rate against human tumor cell WI-38 VA-13.(1). Polysaccharides. Green-algal heteropolysaccharide from Monostroma nitidtim showed strong activity of IC_<50>=18.6 mug/ml.(2).Water-soluble high molecular weight fraction. Inhibition of tumor growth was found for Hijikia ftisiforme(IC_<50>=41.6 mug/ml).(3).Water-soluble low molecular weight fraction. Of the eleven effective species, Hetezrochordaria abietina were found to show highest inhibition rate (IC_<50>=2.7 mug/ml).(4).Tannin-like substances. Ascophyllum nodostim showed high inhibition rate (IC_<50>=10.1 mug/Ml).