The functional localization of short-term memory in the limibic system.

边缘系统中短期记忆的功能定位。

• 批准号: 04670123
• 负责人: YAMAMOTO Tsuneyuki
• 金额: $ 1.41万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04670123/
• 关键词: brain lesion; memory deficit; limbic system; microinjection; working memory; reference memory; delayd matching to sample; short-term memory; 海馬破壊; 扁桃体破壊; 嗅球摘出; 脳内微量注入; スコボラミン; NMDA受容体拮抗剤; Head-twitch; 嗅球; 扁桃体; 海馬

It was attempted to clarify the functional difference in the limbic system in regard to "short-term memory", using several memory tasks.1)Olfactry bulbctomy(OB lesion)markedly impaired both reference and working memory in a 3-panel runway tasks and delayd matching-to-sample(DMTS)performance in a 3-lever operant tasks. Reversal learning in a 2-lever operant task was also markedly impaired by OB lesion.2)Dorsal hippocampal(DH)lesion markedly impaired working memory and DMTS performance, but not reference memory. Furthermore, reversal learning was impaired by DH lesion. Cholinesterase inhibitor physostigmine and tetrahydroaminoacridine(THA)improved the impairments of memory produced by DH lesion. While, impaired of working memory, but not reference memory, was produced by microinjection of muscarinic antagonist scopolamine, nicotinic antagonist mecamylamine, BZP/GABA_A agonist muscimol and chlordiazepoxide, 5-HT_<1A>agonist 8-OH-DA, NMDA antagonist CGS19755 and CPP, and NO synthase inhibi … More tor L-NAME into the dorsal hippocampus.3)Mamillary body(MB)lesion produced impairments of both working and reference memory, but not DMTS performance and reversal learning. While, dorsomedial thalamus(DMT)lesion impaired DMTS performance without affecting both 3-panel runway task and reversal learning. THA failed to improve the impairment of memory in both MB-lesioned rats and DMT-lesioned rats.4)Basolateral amygdaloid lesion impaired the working memory, but not reference memory. Corticomedial amygdaloid lesions failed to impair both working and reference memory. Microinjection of scopolamine and CPP into the basolateral amygdala produced impairment of working memory, but not reference memory.5)Basal forebrain lesion markedly impaired both working and reference memory and DMTS performance. Reversal learning was also impaired by the basal forebrain lesion.In this way, focal brain lesions mentioned above resiults in characteristic dysfunction of memory, depending on lesioned site of brain. These results may provide a useful clue for understanding functional localization of memory. Less

本研究试图通过几种记忆任务来阐明边缘系统在“短时记忆”方面的功能差异。1）嗅球切除术（OB病变）显著损害3-panel跑道任务中的参考记忆和工作记忆以及3-leveloperant任务中的延迟匹配样本（DMTS）表现。2）背侧海马（DH）损伤显著损害工作记忆和DMTS成绩，但不损害参考记忆。此外，DH损伤损害逆转学习。胆碱酯酶抑制剂毒扁豆碱和四氢氨基吖啶（THA）可改善DH损伤引起的记忆障碍。而注射M受体拮抗剂东莨菪碱、烟碱受体拮抗剂美卡拉明、BZP/GABA_A激动剂蝇蕈醇和利血平、5-HT_2<1A>激动剂8-OH-DA、NMDA受体拮抗剂CGS 19755和CPP、NO合酶抑制剂等均能引起工作记忆的损害，而不引起参考记忆的损害。 ...更多信息 3）乳头体毁损后，大鼠的工作记忆和参考记忆均受到损害，但对DMTS操作和逆转学习无影响。然而，背内侧丘脑（DMT）损伤损害DMTS的表现不影响三面板跑道任务和逆转学习。全髋关节置换术不能改善MB损伤大鼠和DMT损伤大鼠的记忆障碍。4）基底外侧杏仁核毁损损害工作记忆，但不影响参考记忆。皮质喜剧性杏仁核病变未能损害工作记忆和参考记忆。基底外侧杏仁核内注射东莨菪碱和CPP可引起工作记忆的损害，但对参考记忆无影响。5）基底前脑损伤可使工作记忆和参考记忆以及DMTS作业均显著受损。基底前脑损害也可损害记忆学习，因此，上述脑局灶性损害可导致特征性的记忆功能障碍，这取决于脑损害部位。这些结果可能为理解记忆的功能定位提供有用的线索。少

项目成果

I.Kitajima: "Working and reference memory in rats in the three-panel runway task following dorsal hippocampal lesions." Japan.J.Pharmacol.58. 175-183 (1992)

I.Kitajima：“背海马损伤后三组跑道任务中大鼠的工作记忆和参考记忆。”

M.Ohno: "Effects of intrahippocampal injections of N-metyl-D-aspartate receptor antagonists and scopolamine on working and reference memory assessed in rats by a three-panel runway task." J.Pharmacol.Exp.Ther.263. 943-950 (1992)

M.Ohno：“通过三组跑道任务评估海马内注射 N-甲基-D-天冬氨酸受体拮抗剂和东莨菪碱对大鼠工作记忆和参考记忆的影响。”

T.Yamamoto: "Ameliorative effects of the centrally active cholinesterase inhibitor, NIK-247, on impairment of working memory in rats." Physiol.Behav.53. 5-10 (1993)

T.Yamamoto：“中枢活性胆碱酯酶抑制剂 NIK-247 对大鼠工作记忆损伤的改善作用。”

M.Ohno: "Working memory induced by a intrahippocampal administration of 8-OH-DAT, a 5-HT_<1A> receptor, in the rat." Europ.J.Pharmacol.234. 29-34 (1993)

M.Ohno：“通过在大鼠海马内施用 8-OH-DAT（一种 5-HT_1A 受体）诱导工作记忆。”

Ohno,M.,et.al.: "Effects of intrahippocampal injections of N-methyl-D-aspartate receptor antagonists and scopolamine on working memory and reference memory assessed in rats by a three-panel runway task." J.Pharmacol.Exp.Ther.263. 943-950 (1992)

Ohno,M.,et.al.：“海马内注射 N-甲基-D-天冬氨酸受体拮抗剂和东莨菪碱对通过三面板跑道任务评估的大鼠工作记忆和参考记忆的影响。”