The clarification of responsible brain region and molecule underlying the expression of drug seeking behavior ("craving")
阐明寻求药物行为(“渴望”)表达背后的负责大脑区域和分子
基本信息
- 批准号:18590060
- 负责人:
- 金额:$ 2.57万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2006
- 资助国家:日本
- 起止时间:2006 至 2007
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We clarified following points involved in the relapse to methamphetamine (MAP) seeking behavior.1. MAP-seeking behavior induced by the MAP-associated cues and MAP-priming injection was attenuated by the intracranial administration of a cannabinoid CB_1 receptor (CB1R) antagonist, AM251 into the nucleus accumbens core (NAC) and prelimbic cortex (PrC). In these regions, the attenuating effects of AM251 on the relapse induced by each stimulus were blocked by the intracranial administration of mecamylamine, a non-selective nAChR antagonist, but not by scopolamine, a non-selective muscarinic ACh receptor (mAChR) antagonist. These findings suggest that relapses to MAP-seeking behavior may be due to the inactivation of nAChR following inhibition of ACh transmission via the activation of CB1Rs.2. The electric foot shock stress in the environment where MAP was self-administered induced MAP-seeking behavior. Meanwhile, CRF receptor antagonist suppressed MAP-seeking behavior. This result suggests … More that MAP-seeking behavior may be due to the activation of CRF receptors.3. The radical scavenger, edaravone suppressed MAP-seeking behavior. This result suggests that MAP-seeking behavior may be due to the activation of the production of radical.4. Intracranial administration of AM251 into the basolateral amygdala (BLA) attenuated the reinstatement of MAP-seeking behavior induced by MAP-associated cue. However, Intracranial administration of AM251 into the BLA did not attenuate MAP-seeking behavior induced by MAP-priming. These findings suggest that the MAP-associated cue and MAP-priming have a different mechanism underlying the expression of MAP-seeking behavior.5. The attenuation of MAP-seeking behavior by AM251 into the BLA was significantly reversed by co-microinjection of AMPA receptor antagonist DNQX into the NAC or PrC. These findings suggest that the MAP-seeking behavior induced by MAP-associated cue may be due to the inactivation of glutamatergic neurotransmission of the BLA to the NAC and PFC via the activation of CB1Rs. Less
我们阐明了以下几点涉及复吸甲基苯丙胺(MAP)寻求行为。通过脑内注射大麻素CB_1受体(CB_1R)拮抗剂AM 251到丘脑核(NAC)和前边缘皮层(PrC),可减弱MAP相关线索和MAP启动注射诱导的MAP寻找行为。在这些区域,AM251对每种刺激诱导的复发的衰减作用被Mecamylamine(一种非选择性nAChR拮抗剂)的颅内给药阻断,但不被东莨菪碱(一种非选择性毒蕈碱ACh受体(mAChR)拮抗剂)阻断。这些发现表明,MAP寻求行为的复发可能是由于通过激活CB1Rs抑制ACh传递后nAChR失活所致。在自身给予MAP的环境中,电击足应激诱导MAP寻求行为。同时,CRF受体拮抗剂抑制MAP寻找行为。这一结果表明 ...更多信息 MAP寻求行为可能是由于CRF受体的激活.自由基清除剂依达拉奉抑制MAP寻求行为。这一结果表明,MAP寻求行为可能是由于自由基的产生激活.将AM251颅内给药至基底外侧杏仁核(BLA)可减弱MAP相关线索诱导的MAP寻找行为的恢复。然而,将AM 251颅内施用到BLA中并没有减弱MAP引发诱导的MAP寻求行为。这些结果表明,MAP相关线索和MAP启动在MAP寻求行为的表达中有不同的机制.将AMPA受体拮抗剂DNQX共同微量注射到NAC或PrC中,可显着逆转AM 251对BLA中MAP寻找行为的减弱。这些结果表明,MAP相关线索诱导的MAP寻找行为可能是由于CB1Rs激活BLA至NAC和PFC的突触能神经传递失活所致。少
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The possibility of nicotinic activators as craving killers in methamphetamine dependence.
烟碱激活剂作为甲基苯丙胺依赖的渴望杀手的可能性。
- DOI:
- 发表时间:2006
- 期刊:
- 影响因子:0
- 作者:Takato Hiranita;et al.
- 通讯作者:et al.
Cannabinoid system serves as a modulator of cognitive impairment arising withdrawal of MDMA
大麻素系统可调节 MDMA 戒断引起的认知障碍
- DOI:
- 发表时间:2006
- 期刊:
- 影响因子:0
- 作者:Nawata;Y.
- 通讯作者:Y.
Cannabinoid system serves as a modulator of cognitive impairment arising withdrawal of MDMA.
大麻素系统可调节 MDMA 戒断引起的认知障碍。
- DOI:
- 发表时间:2006
- 期刊:
- 影响因子:0
- 作者:Nawata;Y.
- 通讯作者:Y.
Association of Catepsin E deficiency with the increase territorial aggresive respoIlse in mice
组织蛋白酶 E 缺乏与小鼠区域攻击性反应增加的关系
- DOI:
- 发表时间:2008
- 期刊:
- 影响因子:0
- 作者:H. Hayashi;et. al.;Nawata Y.;Ohnishi M (第一著者);Shigematsu N.
- 通讯作者:Shigematsu N.
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YAMAMOTO Tsuneyuki其他文献
Immunolocalization of podoplanin/E11/gp38, CD44, and endomucin in the odontoblastic cell layer of murine tooth germs
鼠牙胚成牙本质细胞层中足平蛋白/E11/gp38、CD44和内粘蛋白的免疫定位
- DOI:
10.2220/biomedres.40.133 - 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
KHADIZA Naznin;HASEGAWA Tomoka;NAGAI Tomoya;YAMAMOTO Tomomaya;MIYAMOTO- TAKASAKI Yukina;HONGO Hiromi;ABE Miki;HARAGUCHI Mai;YAMAMOTO Tsuneyuki;YIMIN;QIU Zixuan;SASAKI Muneteru;KUROSHIMA Shinichiro;OHSHIMA Hayato;FREITAS Paulo Henrique Luiz de;LI Minqi;YAW - 通讯作者:
YAW
Histochemical characteristics on minimodeling-based bone formation induced by anabolic drugs for osteoporotic treatment
用于治疗骨质疏松症的合成代谢药物诱导的基于微模型的骨形成的组织化学特征
- DOI:
10.2220/biomedres.42.161 - 发表时间:
2021 - 期刊:
- 影响因子:0
- 作者:
YAMAMOTO Tomomaya;HASEGAWA Tomoka;FRAITAS Paulo Henrique Luiz de;HONGO Hiromi;ZHAO Shen;YAMAMOTO Tsuneyuki;NASOORI Alireza;ABE Miki;MARUOKA Haruhi;KUBOTA Keisuke;MORIMOTO Yasuhito;HARAGUCHI Mai;SHIMIZU Tomohiro;TAKAHATA Masahiko;IWASAKI Norimasa;LI Minqi - 通讯作者:
LI Minqi
口腔嚥下とサルコペニア
口腔吞咽和肌肉减少症
- DOI:
- 发表时间:
2022 - 期刊:
- 影响因子:0
- 作者:
YAMAMOTO Tomomaya;HASEGAWA Tomoka;FRAITAS Paulo Henrique Luiz de;HONGO Hiromi;ZHAO Shen;YAMAMOTO Tsuneyuki;NASOORI Alireza;ABE Miki;MARUOKA Haruhi;KUBOTA Keisuke;MORIMOTO Yasuhito;HARAGUCHI Mai;SHIMIZU Tomohiro;TAKAHATA Masahiko;IWASAKI Norimasa;LI Minqi;堺琴美 - 通讯作者:
堺琴美
YAMAMOTO Tsuneyuki的其他文献
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{{ truncateString('YAMAMOTO Tsuneyuki', 18)}}的其他基金
Verification of paradigm for differentiation, interrelation, tissue organization of epithelial and mesenchymal cells in root formation
根形成过程中上皮细胞和间充质细胞的分化、相互关系、组织组织范式的验证
- 批准号:
22592028 - 财政年份:2010
- 资助金额:
$ 2.57万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A histochemical study of the cementum mineralization in unfixed, undemineralized sections
未固定、未脱矿切片中牙骨质矿化的组织化学研究
- 批准号:
17591900 - 财政年份:2005
- 资助金额:
$ 2.57万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Involvement of the endocannabinoid system in the mechanism of relapse to drug craving
内源性大麻素系统参与药物渴望复发的机制
- 批准号:
14572056 - 财政年份:2002
- 资助金额:
$ 2.57万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Embedment of Sharpey's fibers in human cellular cementum.
夏皮纤维嵌入人体细胞牙骨质中。
- 批准号:
09671842 - 财政年份:1997
- 资助金额:
$ 2.57万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The establishment of animal model for negative syndrome of schizophrenia and its pharmacological annlication
精神分裂症阴性综合征动物模型的建立及其药理作用
- 批准号:
07672462 - 财政年份:1995
- 资助金额:
$ 2.57万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The functional localization of short-term memory in the limibic system.
边缘系统中短期记忆的功能定位。
- 批准号:
04670123 - 财政年份:1992
- 资助金额:
$ 2.57万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
The Behavioral and Pharmacological Study on Experimental Amnesia By using a New Method For Measuring Short-term Memory.
使用测量短期记忆的新方法对实验性遗忘症进行行为和药理学研究。
- 批准号:
01570108 - 财政年份:1989
- 资助金额:
$ 2.57万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
The elucidation of the mechanism of Anti-dimentia effects of nootropic drugs and The establishment of pre-clinical screening method for evaluating its therapeutic potential.
阐明促智药物抗痴呆作用的机制并建立评估其治疗潜力的临床前筛选方法。
- 批准号:
60570094 - 财政年份:1985
- 资助金额:
$ 2.57万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
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