On the distubance of gas exchange in the lung in SIDS.Pathological and ultrastructural observation.
SIDS肺气体交换障碍的病理及超微结构观察。
基本信息
- 批准号:04670350
- 负责人:
- 金额:$ 1.34万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (C)
- 财政年份:1992
- 资助国家:日本
- 起止时间:1992 至 1994
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Histological observation was performed using 28 cases of SIDS (2 months to one and a half years old) , 12 cases of asphyxia ( 1 day to 64 years old) and 6 cases of drowning (4 months to 9 years old) .All SIDS cases showed pulmonary edema and some SIDS cases showed more severe pulmonary edema, compared with that of cases of asphyxia and drowning. But, because SIDS cases showing severe pulmonary edema had received transfusion in hospitals, it was not concluded that severity of pulmonary edema in SIDS cases was significantly higher than that of asphyxia or drowning. Occurrence of microemboli which were composed of plateletes, fibrin and/or white blood cells, and considered as a characteristic finding in asphyxia, were investigated. Occurrence of microemboli was determined by counting of a number of microemboli per 30 microscopic fields by obseving 200 folds. The average numbers of microemboli per 30 microscopic fields in SIDS, asphyxia and drowning were 5.67<plus-minus>6.65,5.78<plus-minus>3.42 and 4.8<plus-minus>1.77, respectivly. SIDS cases were divided into 2 groups ; cases showing acute aspiration of gastric content or milk into the lung and cases without acute aspiration. The average number of microemboli in the group with acute aspiration was 9.86<plus-minus>7.85. On the other hand, that of the group without aspiration was 2.02<plus-mUltrastructural observation was performed using 5 cases of SIDS.Edema in the alveolar walls was observed in all cases. In order to measure severity of edema in the alveolar walls and make it clear if edema in the alveolar wall disturbs gas exchange, thickness of tissue barrier from the surface of the alveolar epithelium from that of endothelial cells, using 3 SIDS cases (3 months to 6 manths old) showing mild postmortem changes and one case of head trauma (one and 3 months old) as a control. The thickness of tissue barrier in SIDS cases were 0.61,0.62, and 0.65 mum, respectively and in the control case was 0.63mum.
对28例SIDS患儿(2个月~ 1岁半)、12例窒息患儿(1天~ 64岁)、6例溺水患儿(4个月~ 9岁)进行组织学观察。所有小岛屿发展中国家均出现肺水肿,部分小岛屿发展中国家的肺水肿较窒息和溺水病例更为严重。但是,由于出现严重肺水肿的SIDS病例在医院接受过输血,因此不能得出SIDS病例的肺水肿严重程度明显高于窒息或溺水的结论。微栓子由血小板、纤维蛋白和/或白细胞组成,被认为是窒息的特征性发现。微栓子的发生是通过每30个显微镜视野观察200次计数微栓子的数量来确定的。SIDS、窒息和溺水患者每30个显微场平均微栓子数分别为5.67<正负>6.65、5.78<正负>3.42和4.8<正负>1.77。SIDS病例分为两组;有胃内容物或乳汁急性吸入肺部的病例和无急性吸入的病例。急性抽吸组平均微栓子数目为9.86个<正负bb0 7.85个。无误吸组为2.02<加5例SIDS进行多结构观察。所有病例均可见肺泡壁水肿。为了测量肺泡壁水肿的严重程度,明确肺泡壁水肿是否干扰气体交换,以3例死后出现轻微变化的SIDS(3个月至6个月大)和1例头部外伤(1个月和3个月大)为对照,比较肺泡上皮表面和内皮细胞之间的组织屏障厚度。SIDS组组织屏障厚度分别为0.61、0.62、0.65 mm,对照组为0.63 mm。
项目成果
期刊论文数量(8)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
大谷勲: "肺に関わる二、三の知見について-法医剖検例を中心として-" 日本法医学雑誌. 48. 379-394 (1994)
Isao Otani:“与肺部相关的一些发现 - 聚焦法医尸检案例 -”《日本法医学杂志》48. 379-394 (1994)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Yasuo BUNAI: "Pathological approaches to SIDS I.Special emphasis on histopathological differences between SIDS and asphyxia" Japanese Journal of Legal Medecine. 46. 405-406 (1992)
Yasuo BUNAI:“SIDS 的病理学方法 I。特别强调 SIDS 和窒息之间的组织病理学差异”日本法医学杂志。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Isao OHYA: "Some findings of the lung in medicolegal autopsy cases. (in Japanese with English abstract)" Japanese Journal of Legal Medicine. 48 (6). 379-394 (1994)
Isao OHYA:“法医学尸检案件中肺部的一些发现。(日文,英文摘要)”《日本法医学杂志》。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
大谷 勲: "肺に関わる二,三の知見について-法医剖検例を中心として-" 日本法医学雑誌. 48. 379-394 (1994)
Isao Otani:“与肺部相关的一些发现 - 聚焦法医尸检案例 -”《日本法医学杂志》48. 379-394 (1994)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
OHYA Isao其他文献
OHYA Isao的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('OHYA Isao', 18)}}的其他基金
Studies on Morphological Changes of Organs due to Traumatic Shock
创伤性休克所致器官形态变化的研究
- 批准号:
02670256 - 财政年份:1990
- 资助金额:
$ 1.34万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
相似国自然基金
胚胎脑发育的分子机理:lgl2(late gestation lung 2)蛋白质的生物学功能的研究
- 批准号:30470854
- 批准年份:2004
- 资助金额:18.0 万元
- 项目类别:面上项目
相似海外基金
Molecular characterization of pulmonary edema: a window to an injured lung
肺水肿的分子特征:了解受损肺部的窗口
- 批准号:
10650385 - 财政年份:2020
- 资助金额:
$ 1.34万 - 项目类别:
Molecular characterization of pulmonary edema: a window to an injured lung
肺水肿的分子特征:了解受损肺部的窗口
- 批准号:
10424478 - 财政年份:2020
- 资助金额:
$ 1.34万 - 项目类别:
Molecular characterization of pulmonary edema: a window to an injured lung
肺水肿的分子特征:了解受损肺部的窗口
- 批准号:
10231005 - 财政年份:2020
- 资助金额:
$ 1.34万 - 项目类别:
Study of the mechanism of lung vascular permeability in pulmonary edema
肺血管通透性在肺水肿中的作用机制研究
- 批准号:
09470325 - 财政年份:1997
- 资助金额:
$ 1.34万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Experimental study on protection of pulmonary edema after lung and heart-lung transplantation
肺及心肺移植术后肺水肿保护作用的实验研究
- 批准号:
01570787 - 财政年份:1989
- 资助金额:
$ 1.34万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
PULMONARY EDEMA, LUNG VASCULAR INJURY AND LUNG FUNCTION
肺水肿、肺血管损伤和肺功能
- 批准号:
3106542 - 财政年份:1976
- 资助金额:
$ 1.34万 - 项目类别:
PULMONARY EDEMA, LUNG VASCULAR INJURY AND LUNG FUNCTION
肺水肿、肺血管损伤和肺功能
- 批准号:
3106543 - 财政年份:1976
- 资助金额:
$ 1.34万 - 项目类别: