The role of cytokines including IL-10 in bronchial asthma

IL-10等细胞因子在支气管哮喘中的作用

• 批准号: 04670453
• 负责人: OKAYAMA Hiroshi
• 金额: $ 1.34万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04670453/
• 关键词: IL-5; IL-10; glucocorticoid; human; monomuclear cell; gene expression; atopy; asthma; ステロイド; 喘息

The effect of glucocorticoids on interleukin 5 induction and its mechanism from normal and atopic human mononuclear cellsThe effect of glucocorticoid, dexamethasone on IL-10 gene expression by human nonocytes, lymmphocytes and peripheral blood mononuclear cells (PBMC) from five healthy volunteers was examined. PBMC expressed IL-10 gene without stimulation and increased by PHA or LPS stimulation, which was suppressed by dexamethasone to 50%. The results indicate that IL-2, IL-4 and IL-5.The results suggest that the regulation of IL-10 gene expression by dexamethasone is different from that of many cytokines. IL-10 may play an important role in the cytokine regulation of alloegie inflammation during glucocorticoid therapy.

糖皮质激素对正常和特应性人单核细胞诱导白细胞介素5的影响及其机制研究糖皮质激素、地塞米松对5名健康志愿者外周血单核细胞（PBMC）、非细胞、淋巴细胞IL-10基因表达的影响。PBMC在没有刺激的情况下表达IL-10基因，PHA和LPS刺激后表达量增加，地塞米松可抑制IL-10基因表达50%。结果表明，IL-2、IL-4和IL-5具有明显的抑制作用。提示地塞米松对IL-10基因表达的调节作用不同于许多细胞因子。在糖皮质激素治疗过程中，IL-10可能在细胞因子调控异体性炎症中发挥重要作用。

项目成果

Fushimi T.,Okayama H.,et al: "The effect of Dexamethasone on IL-10 gene expression by human lymphocyte and monocyte" Respiratory and Critical Care Medicine Am Rev Respir Dis. 149(in press). (1994)

Fushimi T.，Okayama H.，et al：“地塞米松对人淋巴细胞和单核细胞 IL-10 基因表达的影响”呼吸与重症监护医学 Am Rev Respir Dis。

岡山博 他8名: "グルココルチコイドによるインターロイキン5遺伝子発現と産生抑制作用" 呼吸. 14(印刷中). (1994)

Hiroshi Okama 等 8 人：“糖皮质激素对白细胞介素 5 基因表达和产生的抑制”，呼吸系统 14（出版中）。

Hiroshi Okayama et al: "Supressive effect of glucocorticoids on interleukin-5 induction and its mechanism from human peripherial mononuclear cells (in Japanese)" Kokyu. vol 14. (in press) (1994)

Hiroshi Okama 等人：“糖皮质激素对人外周单核细胞白细胞介素 5 诱导的抑制作用及其机制（日语）”Kokyu。

Toshiaki Fushimi, Hiroshi Okayama et al: "The effect of dexamethasone on IL-10 gene expression by human lymphocytes and monocytes" American Journal of Respiratory Celll and Molecular Biology. 10. (in press) (1994)

Toshiaki Fushimi、Hiroshi Okama 等人：“地塞米松对人类淋巴细胞和单核细胞 IL-10 基因表达的影响”美国呼吸细胞与分子生物学杂志。

Hiroshi Okayama et al.: "Glucocorticoids supressed production and gene expression of interleukin-5 by peripheral blood mononuclear cells in atopic patients and normal subjects" J.Allergy and Clinical Immvnology. (in press). (1994)

Hiroshi Okama 等人：“糖皮质激素抑制特应性患者和正常受试者外周血单核细胞白细胞介素 5 的产生和基因表达”J.Allergy and Clinical Immvnology。