ROLE OF BRAIN INTERSTITIAL ADENOSINE IN HYPOXIC VENTILATORY DEPRESSION
脑间质腺苷在缺氧通气抑制中的作用
基本信息
- 批准号:04670451
- 负责人:
- 金额:$ 1.34万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (C)
- 财政年份:1992
- 资助国家:日本
- 起止时间:1992 至 1993
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The purpose of this study is to elucidate the time-dependent change of endogenous adenosine levels in the brain during moderate sustained hypoxia, and to examine its possible relationship with the ventilatory depression seen in the latter falf of sustained hypoxia. In 10 spontaneously breathing cats (carotid sinus and vagal nerve intact), the interstitial levels of adenosine were estimated by a microdialysis method in frontal cortex and nucleus tractus solitarius (NTS) before and during 40 min isocapnic hypoxia (mean PaO2 = 38.3 Torr). The adenosine levels reversibly increased during hypoxia both in the cortex (from 0.70 (〕SY.+-.〔) 0.10 SE to 1.09 (〕SY.+-.〔) 0.13 muM, P <0.05) and in the NTS (from 0.53 (〕SY.+-.〔) 0.08 to 0.95 (〕SY.+-.〔) 0.19 muM, P <0.05) without a significant difference between the two regions. There was a significant positive correlation between the relative rise of adenosine only in the NTS and the relative decline of ventilation after its peak during sustained hypoxia(r=0.70, P<0.05), which may support the hypothesis that the interstitial adenosine in the medulla is involved in the development of hypoxic ventilatory depression in cats.
本研究旨在阐明中度持续缺氧时脑内源性腺苷水平的时间依赖性变化,并探讨其与持续缺氧后期脑内源性腺苷水平下降的可能关系。在10只自主呼吸猫(颈动脉窦和迷走神经完整),腺苷间质水平估计前和40分钟等二氧化碳缺氧(平均PaO 2 = 38.3托),通过微透析方法在额叶皮层和孤束核(NTS)。在缺氧过程中,腺苷水平可逆地增加,在皮层(从0.70 ± 0.05)SY。()0.10 SE至1.09()SY ±。NTS组从0.53 ± 0.13 μ M(P <0.05)下降到0.53 ± 0.13 μ M(P <0.05)。()0.08 ~ 0.95()SY ±.()0.19 μ M,P <0.05),两区间无显著性差异。持续缺氧时,仅孤束核腺苷含量的相对升高与通气量峰值后的相对下降呈显著正相关(r=0.70,P<0.05),这可能支持延髓间质腺苷参与了猫缺氧性通气性抑郁的形成。
项目成果
期刊论文数量(42)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
M.Nishimura: "Effect of theophylline on brain tissue oxygenation during normoxia and hypoxia in humans." J Appl Physiol. 74. 2724-2728 (1993)
M.Nishimura:“茶碱对人类常氧和缺氧期间脑组织氧合的影响。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
S.Kobayashi: "Liver cirrhosis with severe hypoxemia and paradoxical pulmonary vascular response to graded inspiratory oxygen tension." Chest. 103. 958-960 (1993)
S.Kobayashi:“肝硬化伴有严重低氧血症和肺血管对分级吸气氧张力的反常反应。”
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- 发表时间:
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- 影响因子:0
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Nishimura,M.et al: "Effect of theophylline on brain tissue oxygenation during normoxia and hypoxia in bumans" J.Appl.Physiol.74. 2724-2728 (1993)
Nishimura,M.等人:“茶碱对布曼人正常氧和缺氧期间脑组织氧合的影响”J.Appl.Physiol.74。
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Yamamoto,M.et al: "Role of endogenous adenosine in humans:a study with dipyridamole" J.Appl.Physiol.76. 196-203 (1994)
Yamamoto,M.et al:“内源性腺苷在人类中的作用:双嘧达莫的研究”J.Appl.Physiol.76。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Kobayashi,S.et al: "Liver cirrhosis with severe hypoxcma and paradoxic pulmonary vascular response to graded inspiratory oxygen tension" Chest. 103. 958-960 (1993)
Kobayashi,S.et al:“肝硬化伴严重低氧血症和肺血管对分级吸气氧张力的反常反应”胸部。
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- 影响因子:0
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NISHIMURA Masaharu其他文献
NISHIMURA Masaharu的其他文献
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