Studies on the Appearance of Pulsus Paradoxus and its Slignificance in Sleep Apnea Syndrome.

在科学研究补助金（C）期间取得的研究成果概述如下。总结了奇脉发生率的临床结果，并使用脉搏血氧仪（使用补助金购买）进行了一项关于24小时SaO2水平测量的新研究。[1]1992年和1993年因可疑SAS就诊的145例（71例和74例）中，66例因SAS而入院接受详细检查或治疗。阻塞性呼吸暂停61例，中枢性呼吸暂停5例。在向40例阻塞性SAS患者提供有关本研究目的的完整信息后，获得了他们的知情同意书。结果：1）40例患者中，26例（1992年13/21例，1993年13/19例）出现奇脉; 2）奇脉发生率在非REM睡眠时较高，1993年13/19例，1994年13/19例，1995年13/19例，1996年13/19例，1997年13/19例，1997年13/19例，1998年13/19例，1999年13/19例，1999年13/19例，1992年13/19例，1993年13/19例，1993年13/19例，1993年13/19例，1993年13/19例，1994年13/19例，1993年13/19例，199 ...更多信息 与阻塞性吸气时Pes的显著降低相一致。3)有奇脉的患者明显比无奇脉的患者年轻，Pes明显降低。4)经鼻持续气道正压通气（CPAP）治疗可通过改善呼吸模式和缓解奇脉来迅速恢复Pes。总之，阻塞性SAS患者中奇脉的发生率为65%，因此阻塞性SAS作为Pes过度降低的一个标志具有临床意义。经鼻CPAP治疗被认为是有效的SAS患者过度降低Pes。[2]心血管疾病患者24小时血氧饱和度变化研究：使用研究补助金购买的脉搏血氧仪每天24小时监测血氧饱和度变化。结果如下：（1）夜间SaO_2下降随心功能恶化而加重，提示24小时SaO_2监测可作为一种有效的心功能评价方法。（2）Fallt四联症患者24小时SaO_2监测呈夜间高于白天的反常变化。少

Research results obtained during the periods of Grant-in-Aid for Scientific Research(C) are outlined below. Clinical findings on the incidence of pulsus paradoxus were summed up, and a new study on the 24-hr measurement of SaO2 levels progressed using a pulse oximeter (purchases using the grant).[1] Study on the incidence of pulsus paradoxus and its significanceOf the 145 outpatients (71 in 1992 and 74 in 1993) referred to us for suspected SAS, 66 were admitted to out hospital for more detailed examinations or its treatment. The apnea type was obstructive in 61 and central in 5. Informed consent was obtained from 40 patients with obstructive SAS after giving them full information on the objectives of out study. Intrathoracic pressure (Pes) and continuous blood pressure were measured in these 40 patients under the polysomnography.Results : 1) Of the 40 patients, 26 (13/21 in 1992 and 13/19 in 1993) showed pulsus paradoxus.2) The incidence of pulsus paradoxus was higher during non-REM sl … More eep and coincided with marked decreases in Pes during obstructed inspiration. 3) Patients with pulsus paradoxus were significantly younger than those without it and showed significant decreases in Pes. 4) Appropriate treatment with nasal CPAP promptly normalized Pes by improving respiration patterns and resolved pulsus paradoxus. In conclusion, the incidence of pulsus paradoxus was 65% in patients with obstructive SAS.Therefore, obstructive SAS is clinically significant as a sign of excessive decrease in Pes. Nasal CPAP therapy was considered to be effective in SAS patients with excessive decreases in Pes.[2] Study on 24-hr changes in SaO2 levels in patients with cardiovascular diseases.Changes in SaO2 levels were monitored 24 hr per day using a pulse oximeter purchased using the study grant. Results : 1) Decreases in SaO2 durng the night progressed with deterioration of function, suggesting that 24-hr SaO2 monitoring may be a usefcardiac function evaluation method.2) In patients with tetralogy of Fallt, 24-hr monitoring of SaO2 levels showed a paradoxical variation, in which they are higher at might than in the daytime. Less