Studies on the Appearance of Pulsus Paradoxus and its Slignificance in Sleep Apnea Syndrome.

奇脉的出现及其在睡眠呼吸暂停综合征中的意义研究。

• 批准号: 04670562
• 负责人: SHIOMI Toshiaki
• 金额: $ 1.28万
• 依托单位: Aichi Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04670562/
• 关键词: Sleep apnea; Bolld pressure; Pulsus paradoxus; Pulse oximetry; Intrathoracic pressure; パルスオキシメトリー

Research results obtained during the periods of Grant-in-Aid for Scientific Research(C) are outlined below. Clinical findings on the incidence of pulsus paradoxus were summed up, and a new study on the 24-hr measurement of SaO2 levels progressed using a pulse oximeter (purchases using the grant).[1] Study on the incidence of pulsus paradoxus and its significanceOf the 145 outpatients (71 in 1992 and 74 in 1993) referred to us for suspected SAS, 66 were admitted to out hospital for more detailed examinations or its treatment. The apnea type was obstructive in 61 and central in 5. Informed consent was obtained from 40 patients with obstructive SAS after giving them full information on the objectives of out study. Intrathoracic pressure (Pes) and continuous blood pressure were measured in these 40 patients under the polysomnography.Results : 1) Of the 40 patients, 26 (13/21 in 1992 and 13/19 in 1993) showed pulsus paradoxus.2) The incidence of pulsus paradoxus was higher during non-REM sl … More eep and coincided with marked decreases in Pes during obstructed inspiration. 3) Patients with pulsus paradoxus were significantly younger than those without it and showed significant decreases in Pes. 4) Appropriate treatment with nasal CPAP promptly normalized Pes by improving respiration patterns and resolved pulsus paradoxus. In conclusion, the incidence of pulsus paradoxus was 65% in patients with obstructive SAS.Therefore, obstructive SAS is clinically significant as a sign of excessive decrease in Pes. Nasal CPAP therapy was considered to be effective in SAS patients with excessive decreases in Pes.[2] Study on 24-hr changes in SaO2 levels in patients with cardiovascular diseases.Changes in SaO2 levels were monitored 24 hr per day using a pulse oximeter purchased using the study grant. Results : 1) Decreases in SaO2 durng the night progressed with deterioration of function, suggesting that 24-hr SaO2 monitoring may be a usefcardiac function evaluation method.2) In patients with tetralogy of Fallt, 24-hr monitoring of SaO2 levels showed a paradoxical variation, in which they are higher at might than in the daytime. Less

在科学研究资助(C)期间所取得的研究成果概述如下：总结了关于矛盾脉的临床发现，并进行了一项使用脉搏血氧仪测量24小时SaO2水平的新研究（使用拨款购买）145例疑似SAS的门诊患者（1992年71例，1993年74例）中，66例住院接受更详细的检查或治疗。呼吸暂停61例为阻塞性，5例为中枢性。在向40名阻塞性SAS患者提供了研究目的的全部信息后，获得了他们的知情同意。在多导睡眠描记术下测量40例患者的胸内压（Pes）和连续血压。结果：1)在40例患者中，有26例（1992年13/21例，1993年13/19例）出现矛盾脉。2)在非快速眼动睡眠时，似然脉的发生率较高，且与吸气梗阻时，似然脉的发生率显著降低相吻合。3)有矛盾脉的患者明显比无矛盾脉的患者年轻，Pes明显降低。4)适当的鼻CPAP治疗可通过改善呼吸方式和解决矛盾脉迅速使Pes正常化。总之，在梗阻性SAS患者中，矛盾脉的发生率为65%。因此，阻塞性SAS作为Pes过度减少的标志在临床上具有重要意义。鼻CPAP治疗被认为是有效的SAS患者过度降低Pes. bbb心血管疾病患者24小时SaO2水平变化的研究使用使用研究经费购买的脉搏血氧仪每天24小时监测SaO2水平的变化。结果：1)夜间SaO2随功能恶化而降低，提示24小时SaO2监测可能是一种实用的心功能评价方法。2)在Fallt四联症患者中，24小时SaO2水平监测显示出矛盾的变化，在夜间高于白天。少

项目成果

Shiomi,T,et al.: "Short-term variation in blood pressure during obstructire sleep apnea and the appearance of pulses paradoous" Ther.Res.13. 4027-4031 (1992)

Shiomi,T,et al.：“阻塞性睡眠呼吸暂停期间血压的短期变化以及脉搏异常的出现”Ther.Res.13。

Shiowi,T,et al.: "Flom velocity paradoxus and pulsus paradoxus in obstractive sleep apnes syndroee" Chest. 103. 1629-1631 (1993)

Shiowi，T 等人：“阻塞性睡眠呼吸暂停综合征中的弗洛姆速度悖论和脉搏”胸部。

塩見利明,渡辺務: "睡眠リズムと循環器疾患" クリニカ. 19. 647-651 (1992)

Toshiaki Shiomi、Tsutomu Watanabe：“睡眠节律与心血管疾病”临床杂志 19. 647-651 (1992)。

Shiomi T,et al.: "Short-term variation in blood pressure during obstructive sleep apnea and the appearance of pulsus paradoxus" Ther.Res.13. 4027-4031 (1992)

Shiomi T 等人：“阻塞性睡眠呼吸暂停期间血压的短期变化和奇脉的出现”Ther.Res.13。

Shiomi T,et al: "Flow velocity paradoxus and pulsus paradoxus in obstructive sleep apnea syndrome" Chest. 103. 1629-1631 (1993)

Shiomi T 等人：“阻塞性睡眠呼吸暂停综合征中的流速悖论和脉搏”胸部。