MRI of Experimental and Human Osteoporosis -Efficacy of Chemical Fat Saturation Imaging-

实验性和人体骨质疏松症的 MRI -化学脂肪饱和成像的功效 -

• 批准号: 04670669
• 负责人: SUGIMURA Kazuro
• 金额: $ 0.83万
• 依托单位: Shimane Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04670669/
• 关键词: osteoporosis; MRI; chemical shift; bone substance; chemical shift imaging

Osteoporosis was the one of important disease in coming aged society. This investigation was to assess the value of MRI in evaluation of osteoporosis. Conventional spin-echo technique could not demonstrate changes of bone substance in patients with osteoporosis because signal of bone substance was much smaller than fat signal in this imaging sequence. We used chemical fat saturation(FS)MR imaging in the evaluation of bone substance that could reduce fat signal. Osteoporotic rabbits and nomal rabbits were used in experimental study. Fifty females aged 18 to 75 year-old were included in human study. Conventional T1-, T2 and FS-T1-weighted images were obtained in these rabbits. Signal intensity ratio on FS-T1-weighted and FS-T2-weighted images of osteoporotic rabbits were both statistically lower than that of normal rabbits. Quantitative measurements of T1 and T2 relaxation times on FS of osteoporotic rabbits were shorter than that of normal ones. Signal intensity ratio on FS-T1 weighted images of vertebral bone marrow of females were also calculated. The results showed a decrease of signal intensity ratio with advancing age. These results suggest that FS imaging can depict tha change of trabecular matrix collagen that occur in such cases like osteoporosis or aging.

骨质疏松症是老龄化社会的重要疾病之一。本研究旨在探讨MRI在骨质疏松症诊断中的价值。常规自旋回波技术不能显示骨质疏松患者骨质的变化，因为在该成像序列中骨质信号远小于脂肪信号。我们使用化学脂肪饱和（FS）MR成像评价骨质，可以减少脂肪信号。实验采用骨质疏松家兔和正常家兔。50名年龄在18至75岁的女性被纳入人体研究。常规T1、T2和FS-T1加权像。骨质疏松兔FS-T1加权和FS-T2加权图像的信号强度比均低于正常兔，差异有统计学意义。定量测定FS的T1和T2弛豫时间，结果表明，实验组FS的T1和T2弛豫时间均短于正常组。计算女性椎体骨髓FS-T1加权像信号强度比。结果表明，随年龄增长，信号强度比下降。结果提示FS成像可反映骨质疏松、衰老等情况下骨小梁基质胶原的变化。

项目成果

杉村和朗: "椎体骨基質の加齢および骨粗鬆症における変化とそのMRI像に関する基礎的、臨床的研究" INNERVISON. 7. 23-24 (1993)

Kazuo Sugimura：“衰老和骨质疏松症期间椎骨基质变化及其 MRI 图像的基础和临床研究”INNERVISON。7. 23-24 (1993)。

杉村和朗他: "椎体骨基質の加齢および骨粗鬆症における変化とそのMRI像に関する基礎的・臨床的研究" INNERVISION. 7. 23-24 (1993)

Kazuo Sugimura 等人：“衰老和骨质疏松症过程中椎骨基质变化的基础和临床研究及其 MRI 图像”INNERVISION。 7. 23-24 (1993)

Sugimura K.: "MRI of Experimental and Human Osteoporosis -Efficacy of Chemical Fat Saturation Imaging-" Innervision. 7. 23-24 (1993)

Sugimura K.：“实验性和人类骨质疏松症的 MRI -化学脂肪饱和成像的功效 -”Innervision。

内田伸恵: "骨粗鬆症のMRI診断:Chemical Fat Saturation法の有用性" 日本磁気共鳴医学会雑誌. 13. 341-346 (1993)

Nobue Uchida：“骨质疏松症的 MRI 诊断：化学脂肪饱和法的有用性”日本磁共振医学会杂志 13. 341-346 (1993)。

Uchida N.: "MRI osteoporosis -Efficacy of chemical fat saturation imaging-" Japanese Journal Magnetic Resonance in Medicine. 13. 341-346 (1993)

Uchida N.：“MRI 骨质疏松症 - 化学脂肪饱和成像的功效 -” 日本医学磁共振杂志。