Research of Proton and Carbon ion bean irradiation and its diagnostic methods

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Proton beam or carbon ion beam irradiation are known to have achieved their excellent dose distribution. However, their biological and molecular difference are largely unknown. Hyogo Ion Beam Center is the first to have both proton and carbon ion beams in the world. With using these advantages, we firstly report that both proton and carbon ion beams could repress metastatic ability, not only their cytotoxicity.(Cancer Res, 2005;65(1): 113-120)In the next, we reported that photon and carbo ion beam showed additive effect in vitro (Radiother and Oncol. 2004;71(2):207-211). Moreover, we investigated several diagnostic methods for more accurate diagnosis to improve outcomes. Especially, FDG-PET have powerful prognostic ability in the management of non-small cell lung cancer (J Clin Oncol, 2005; 23(6): 1136-1143). MRI also showed sharp diagnostic accuracy with using STIR turbo spin-echo (Radiology, 2004;231(3):872-9)