Research of Proton and Carbon ion bean irradiation and its diagnostic methods

质子、碳离子束照射及其诊断方法的研究

• 批准号: 15390362
• 负责人: SUGIMURA Kazuro
• 金额: $ 7.36万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15390362/
• 关键词: Proton beam irradiation; Carbon ion beam; FDG-PET; Prostate Cancer; Lung Cancer; Soft Tissue Tumor; MRI; MRS; 骨軟部肉腫; 悪性黒色腫; 磁気共鳴画像; PET

Proton beam or carbon ion beam irradiation are known to have achieved their excellent dose distribution. However, their biological and molecular difference are largely unknown. Hyogo Ion Beam Center is the first to have both proton and carbon ion beams in the world. With using these advantages, we firstly report that both proton and carbon ion beams could repress metastatic ability, not only their cytotoxicity.(Cancer Res, 2005;65(1): 113-120)In the next, we reported that photon and carbo ion beam showed additive effect in vitro (Radiother and Oncol. 2004;71(2):207-211). Moreover, we investigated several diagnostic methods for more accurate diagnosis to improve outcomes. Especially, FDG-PET have powerful prognostic ability in the management of non-small cell lung cancer (J Clin Oncol, 2005; 23(6): 1136-1143). MRI also showed sharp diagnostic accuracy with using STIR turbo spin-echo (Radiology, 2004;231(3):872-9)

已知质子束或碳离子束照射已实现其优异的剂量分布。然而，它们的生物学和分子差异在很大程度上是未知的。兵库离子束中心是世界上第一个同时拥有质子和碳离子束的中心。利用这些优点，我们首先报道质子和碳离子束不仅可以抑制细胞毒性，而且可以抑制转移能力。(Cancer Res, 2005;65(1): 113-120)接下来，我们报道光子和碳离子束在体外表现出相加效应(Radiother and Oncol. 2004;71(2):207-211)。此外，我们研究了几种诊断方法，以实现更准确的诊断，从而改善结果。尤其是，FDG-PET在非小细胞肺癌的治疗中具有强大的预后能力(J Clin Oncol，2005；23(6)：1136-1143)。使用 STIR 涡轮自旋回波，MRI 还显示出极高的诊断准确性（放射学，2004 年；231(3):872-9）

项目成果

粒子線治療:陽子線治療と炭素イオン線治療

粒子束治疗：质子束治疗和碳离子束治疗

• 发表时间: 2005
• 期刊: Mebio Oncology 2
• 作者: 山本憲;伏見育崇;三木幸雄;富樫かおり;村上 昌雄
• 通讯作者: 村上 昌雄

Centrically reordered inversion recovery half-Fourier single-shot turbo spin-echo sequence: improvement of the image quality of oxygen-enhanced MRI

• DOI: 10.1016/j.ejrad.2004.02.007
• 发表时间: 2004-11-01
• 期刊: EUROPEAN JOURNAL OF RADIOLOGY
• 影响因子: 3.3
• 作者: Ohno, Y;Hatabu, H;Sugimura, K
• 通讯作者: Sugimura, K

Akagi T: "Ridge filter design for proton therapy at Hyogo Jon Beam Medical Center."Phys Med Biol. 48(22). N301-N312 (2003)

Akagi T：“兵库 Jon Beam 医疗中心质子治疗的脊过滤器设计。”Phys Med Biol。

Ishikawa T: "Solitary fibrous tumor in the pelvic space."Urol Res. 32(1). 49-50 (2004)

Ishikawa T：“骨盆腔内的孤立性纤维性肿瘤。”Urol Res。

Hinata N: "Radiation induces p53-dependent cell apoptosis in bladder cancer cells with wild-type-p53 but not in p53-mutated bladder cancer cells."Urol Res.. 31(6). 387-396 (2003)

Hinata N：“辐射会在野生型 p53 的膀胱癌细胞中诱导 p53 依赖性细胞凋亡，但在 p53 突变的膀胱癌细胞中则不会。”Urol Res.. 31(6)。