Analysis of Bone marrow Dynamics by Magnetic Resonance

1.建立了STIR和快速STIR的最佳脉冲序列，并将其应用于血液病骨髓MRI的评价。在再生障碍性贫血和多发性骨髓瘤中，获得了较高的敏感性和特异性。而慢性粒细胞白血病和骨髓增生异常综合征的敏感性和特异性约为50%。2.作为磁化传递对比应用的前期工作，对膝关节MRI进行了评价。关节液和透明软骨之间有很好的对比。蛋白多糖和胶原蛋白可能是造影剂的两个关键来源。因此，MTC可以应用于骨髓增生异常综合征的成像，其中蛋白多糖和胶原蛋白也是主要成分。3.31P磁共振波谱的计划，但它仍在进行中。切除猪腰椎，31P MRS测量失败。组织学关联正在进行中。

1.Optimal pulse sequences were established in both STIR and fast STIR.The results were applied in the evaluation of the bone marrow MRI of hematological disorders. In aplastic anemia and multiple myeloma, high sensitivity and specificity were obtained. However in chronic myelocytic leukemia and myelodysplastic syndrome, senitivity and specificity were about 50%.2.As a preliminary work of application of magnetization transfer contrast, knee joint MRI was evaluated. Here a good contrast was obtained between joint fluid and hyaline cartilage. Probably proteoglycan and collagen are the 2 key sources of contrast. Hence, MTC can be applied to the imaging of bone marrow interstitium, where proteoglycan and collagen are also major compornents.3.31P Magnetic resonance spectroscopy was planned, but it is still underway. Pig lumbar spine was excised and 31P MRS was measured without success. Histopathological correlation is underway.