Analysis of Bone marrow Dynamics by Magnetic Resonance

1.在搅拌和快速搅拌中均建立了最优脉冲序列。结果应用于血液系统疾病的骨髓MRI评价。在再生障碍性贫血和多发性骨髓瘤中，具有较高的敏感性和特异性。而在慢性髓细胞白血病和骨髓增生异常综合征中，敏感性和特异性约为50%。作为磁化转移造影剂应用的前期工作，对膝关节MRI进行了评价。可见关节液和透明软骨的良好对比。可能蛋白聚糖和胶原蛋白是两种主要的对比来源。因此，MTC可以应用于骨髓间质成像，其中蛋白多糖和胶原蛋白也是主要成分。3.31 p磁共振波谱是计划的，但仍在进行中。切除猪腰椎，测31P MRS，未成功。组织病理学相关性正在进行中。

1.Optimal pulse sequences were established in both STIR and fast STIR.The results were applied in the evaluation of the bone marrow MRI of hematological disorders. In aplastic anemia and multiple myeloma, high sensitivity and specificity were obtained. However in chronic myelocytic leukemia and myelodysplastic syndrome, senitivity and specificity were about 50%.2.As a preliminary work of application of magnetization transfer contrast, knee joint MRI was evaluated. Here a good contrast was obtained between joint fluid and hyaline cartilage. Probably proteoglycan and collagen are the 2 key sources of contrast. Hence, MTC can be applied to the imaging of bone marrow interstitium, where proteoglycan and collagen are also major compornents.3.31P Magnetic resonance spectroscopy was planned, but it is still underway. Pig lumbar spine was excised and 31P MRS was measured without success. Histopathological correlation is underway.