权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Carcinogenetic Effect of Bile on the Development of Gallbladder Carcinoma

胆汁对胆囊癌发展的致癌作用

基本信息

批准号：
04670767
负责人：
SHIRAI Yoshio
金额：
$ 0.32万
依托单位：
Niigata University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C).
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1993
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04670767/
关键词：
Gallbladder neoplasms Anomalous union of pancreaticobiliary ductal system Adenomyomatosis of the gallbladder N-nitrosobis (2-oxopropyl) amine Experimental gallbladder carcinoma Lithogenic diet Gallbladder bile Bile acids and salts 膵管胆道合流異常

项目摘要

BACKGROUND.Changes in bile composition induce the development of gallbladder cancer.METHODS.The aim of this study is to clarify the role of gallbladder bile in the development of gallbladder cancer experimentally and clinically.(1) Experimental sutdy. The effect of lithogenic diet on biliary tract neoplasms induced by oral administration of BOP in female hamsters (n=50) was examined. (2) Clinical Study. Gallbladder bile composition was examined in the cases of gallbladder cancer (n=15), anomalous union of pancreaticobiliary ductal system (n=13), and segmental adenomyomatosis (n=20), and compared with that of control patients (n=13).RESULTS.(1) Experimental study. The incidence of biliary tract neoplasms in the hamsters fed with BOP plus inthogenic diet was similar to that in those fed with BOP plus normal diet. (2) Clinical Study. In gallbladder cancer, the concentrations of total bile acids (29.3(〕SY.+-.〔)21.5mumol/ml) and secondary bile acids (7.7(〕SY.+-.〔)5.4mumol/ml) were significantly lower than those of normal patients (P<0.001). Also in anomalous union of pancreaticobiliary ductal system and segmental adenomyomatosis, the concentrations of total bile acids (56.1(〕SY.+-.〔)64.8 and 74.8(〕SY.+-.〔)19.3, respectively) and secondary bile acids (6.8(〕SY.+-.〔)7.0 and 13.7(〕SY.+-.〔)15.2, respectively) were significantly lower than normal patients (P<0.01).CONCLUSIONS.(1) Experimental study. In hamsters, lithogenic diet does not promote BOP (20ppm)-induced biliary tract neoplasms. (2) Clinical study. Lower concentrations of bile acids are characteristic in the gallbladder bile of gallbladder cancer and precancerous conditions. That is, it is unlikely that bile acids in gallbladder contribute to the development of gallbladder cancer. Further investigations are mandatory to elucidate carcinogenic factors in gallbladder bile.

背景：胆汁成分的改变诱导胆囊癌的发生。方法：本研究的目的是通过实验和临床阐明胆囊胆汁在胆囊癌发生中的作用。(1)实验研究在雌性仓鼠（n=50）中检查了致石饮食对口服BOP诱导的胆道肿瘤的影响。(2)临床研究。本文对胆囊癌15例、胰胆管系统畸形愈合13例、节段性腺肌瘤病20例的胆囊胆汁成分进行了测定，并与对照组13例进行了比较。(1)实验研究。BOP加营养饲料组与BOP加普通饲料组的胆道肿瘤发生率相似。(2)临床研究。胆囊癌患者血清总胆汁酸浓度（29.3 ± 0.01）ng/ml，对照组（10.0 ± 0.01）ng/ml。21.5 μ mol/ml）和次级胆汁酸7.7 μ mol/ml。（5.4 μ mol/ml）明显低于正常人（P<0.001）。胰胆管系统异常结合和节段性腺肌瘤病的总胆汁酸浓度（56.1 ± 0.05）SY。（）64.8和74.8（）SY. ±.（）19.3）和次级胆汁酸（6.8（）SY. ()7.0和13.7（）SY. ±.（分别为15.2）明显低于正常人（P<0.01）。(1)实验研究。在仓鼠中，致石饮食不会促进BOP（20 ppm）诱导的胆道肿瘤。(2)临床研究。胆囊癌和癌前病变的胆囊胆汁中胆汁酸浓度较低是其特征。也就是说，胆囊中的胆汁酸不太可能有助于胆囊癌的发展。进一步的调查是强制性的，以阐明胆囊胆汁中的致癌因素。