The research of cardioprotective effects of nucleoside transport inhibition.

首先，我们研究了在心脏不能完全维持低温和ATP分解的情况下，核苷转运抑制剂（NTI）是否具有心脏保护作用。在心肌保护不佳导致心肌ATP降解的情况下，NTI具有与内源性腺苷积累有关的心肌保护作用。第二，研究阿卡地新与NTI联合应用对深低温缺血心肌的保护作用。单独使用这些药物并不有效，但阿卡地辛和NTI联合使用增加了内源性腺苷，改善了心肌保护。

First, we investigated whether uncleoside transport inhibitor (NTI) have cardioprotective effect in case that hearts were not maintained hypothemia completely and ATP was broken down. In case myocardial ATP degradate due to poor myocardial protection, NTI has a cardioprotective effect related to acculation of endogeneous addenosine.Second, we tested the cardioprotective effect of the combined use of acadesine and NTI on the deep hypothermic ischemia. Individual use of these agents did not work effectively, but the combined use of both acadesine and NTI increased the endogenous adenosine and improved myocardial protection.