The research of cardioprotective effects of nucleoside transport inhibition.

核苷转运抑制的心脏保护作用研究。

• 批准号: 04670832
• 负责人: MASUDA Munetaka
• 金额: $ 1.34万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04670832/
• 关键词: Nucleoside transport inhibition; Adenosine; Acadesine; 心筋保護; 低温心筋虚血; Nucleoside Transport inhibitor; ATP

First, we investigated whether uncleoside transport inhibitor (NTI) have cardioprotective effect in case that hearts were not maintained hypothemia completely and ATP was broken down. In case myocardial ATP degradate due to poor myocardial protection, NTI has a cardioprotective effect related to acculation of endogeneous addenosine.Second, we tested the cardioprotective effect of the combined use of acadesine and NTI on the deep hypothermic ischemia. Individual use of these agents did not work effectively, but the combined use of both acadesine and NTI increased the endogenous adenosine and improved myocardial protection.

首先，我们研究了在心脏不能完全维持低温和ATP分解的情况下，核苷转运抑制剂（NTI）是否具有心脏保护作用。在心肌保护不佳导致心肌ATP降解的情况下，NTI具有与内源性腺苷积累有关的心肌保护作用。第二，研究阿卡地新与NTI联合应用对深低温缺血心肌的保护作用。单独使用这些药物并不有效，但阿卡地辛和NTI联合使用增加了内源性腺苷，改善了心肌保护。

项目成果

M,Masuda: "Effects of nucleoside transport inhibition on long-term ex vivo preservation of canine fearts." J Thorac Cardiovascular Surg. 104. 1610-1617 (1992)

M，Masuda：“核苷转运抑制对犬恐惧的长期离体保存的影响。”

益田宗孝: "酸素加晶質液性心筋保護液の臨床的評価及びNTIによる心筋保護back-up効果の実験的検討" 日本心臓血管外科学会誌. 22. 165-168 (1993)

Munetaka Masuda：“含氧结晶液体心麻痹液的临床评价和 NTI 心肌保护备用效果的实验研究”日本心血管外科学会杂志 22. 165-168 (1993)。

T,Nishida: "Combination of acadesine and nucleoside transport inhibitor enhances myocardial protection by endogenous adenosine in hypothermnic ischemia." XV European Section Meeting of International Society for Heart Research. 321-325 (1994)

T，Nishida：“阿卡地辛和核苷转运抑制剂的组合可增强低温缺血中内源性腺苷的心肌保护作用。”

Munetaka Masuda: "Effects of nucleoside transport inhibition on long-term ex vivo preservation of caine hearts" J.Thovac.Cardiovasc.Surg.104. 1610-1617 (1992)

Munetaka Masuda：“核苷转运抑制对卡因心脏长期离体保存的影响”J.Thovac.Cardiovasc.Surg.104。

益田宗孝: "酸素加晶質液心筋保護液の臨床的評価及びNTIによる心筋保護back-up効果の実験的検討" 日本心臓血管外科学会誌. 22. 165-168 (1993)

Munetaka Masuda：“含氧晶体心脏停跳液的临床评价和 NTI 心肌保护备用效果的实验研究”日本心血管外科学会杂志 22. 165-168 (1993)。