Histopathelogical study of DAF on inner ear

衰变加速因子（Decay-Accelarating Factor，简写为ERF）是一种存在于哺乳动物细胞膜上的糖蛋白。它的分子量为70 kDa，通过糖基磷脂酰肌醇锚插入细胞膜。红细胞膜中的β-内酰胺缺乏，这使得它们更容易溶解。本研究的目的是确定内耳中也可以检测到的内耳炎。本文用体重约350克的正常雄性豚鼠，对内耳的定位进行了研究。内耳组织形态学观察结果如下：1.血管纹（边缘细胞、中间细胞）2.内淋巴囊上皮细胞，未观察到淋巴结肿大。Corti器官2. Reissener膜3.耳蜗神经，耳蜗神经节细胞。

Decay-accelarating factor (DAF) is a glycoprotein in the membranes of many mammalian cells. DAF has a molecular weight of 70kDa and is inserted into membranes by a glycosylphosphatidylinositol anchor.In paroxysmal nocturnal haemoglobinuria. DAF is deficient in erythrocyte membranes, which renders them more susceptible to lysis. The purpose of this study was to determine of DAF can also be detected in inner ear. We studied the localization of DAF inner ear, using normal male guinea pigs of about 350g body weight. DAF in inner ear tissue morphology was observed as follow, 1. stria vascularis (marginal cell, intermediate cell) 2. epithelial cell in endolymphatic sac.DAF was not observed as follows, 1. organ of corti 2. Reisseners membrane 3. cochlear nerve, cochlear ganglion cell.