Histopathelogical study of DAF on inner ear
Histopathelogical study of DAF on inner ear
批准号:
04671040
负责人:
HARADA Tamotsu
金额:
$1.28万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for General Scientific Research (C)
财政年份:
1992
资助国家:
日本
项目状态:
已结题
起止时间:
1992 至 1993
中文摘要
加速衰变因子(DAF)是一种存在于许多哺乳动物细胞膜中的糖蛋白。DAF分子量为70kDa,通过糖基磷脂酰肌醇锚点插入膜中。在阵发性夜间血红蛋白尿。DAF在红细胞膜中缺乏,这使得它们更容易溶解。本研究的目的是确定在内耳中也可以检测到DAF。我们用体重约350g的正常雄性豚鼠研究DAF内耳的定位。内耳组织形态的DAF观察如下:1。血管纹(边缘细胞,中间细胞)内淋巴囊上皮细胞。未观察到DAF如下:1。corti的翻译结果:Reisseners膜耳蜗神经,耳蜗神经节细胞
英文摘要
Decay-accelarating factor (DAF) is a glycoprotein in the membranes of many mammalian cells. DAF has a molecular weight of 70kDa and is inserted into membranes by a glycosylphosphatidylinositol anchor.In paroxysmal nocturnal haemoglobinuria. DAF is deficient in erythrocyte membranes, which renders them more susceptible to lysis. The purpose of this study was to determine of DAF can also be detected in inner ear. We studied the localization of DAF inner ear, using normal male guinea pigs of about 350g body weight. DAF in inner ear tissue morphology was observed as follow, 1. stria vascularis (marginal cell, intermediate cell) 2. epithelial cell in endolymphatic sac.DAF was not observed as follows, 1. organ of corti 2. Reisseners membrane 3. cochlear nerve, cochlear ganglion cell.
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T.Harada: "Mesurement of Anaphylatoxin Activity durin surgery" Acta Otolaryngol. 501. 88-91 (1993)
T.Harada:“手术期间过敏毒素活性的测量”Acta Otolaryngol。
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T.Harada: "The effect of Anaphylatoxin Component on Inner ear Damage" Acta Otolaryngol. 112. 265-271 (1992)
T.Harada:“过敏毒素成分对内耳损伤的影响”Acta Otolaryngol。
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原田 保: "腎不全患者の内耳疾患と免疫複合体の関連について" Equilibrium Res. 9. 55-59 (1993)
Tamotsu Harada:“肾衰竭患者内耳疾病与免疫复合物的关系”平衡研究 (Equilibrium Res)。 9. 55-59 (1993)
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K.Hong, T.Harada: "Binding ability of complement receptor CRI to C3 bound on the surface of M^+ group A streptococci" Immunology. 80. 640-644 (1993)
K.Hong、T.Harada:“补体受体 CRI 与 M 组 A 链球菌表面结合的 C3 的结合能力”免疫学。
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T.Harada: "The mechanism of immune complex-mediated inner ear diseases." Ann Otol Rhinol Laryngol. 101. 72-77 (1992)
T.Harada:“免疫复合物介导的内耳疾病的机制。”
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共 12 条
Superoxide distribution in the inner ear in inner ear disorders
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批准号:23592502
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.5万
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财政年份:2011
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负责人:HARADA Tamotsu
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依托单位:
Bio-morphological studies of apoptotic with non-apoptotic dying cells in developing inner ear of mouse embryos.
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批准号:15591839
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.86万
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财政年份:2003
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负责人:HARADA Tamotsu
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依托单位:
The histologic and functional study of macrophage in the endolymphatic sac.
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批准号:11671715
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.28万
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财政年份:1999
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负责人:HARADA Tamotsu
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依托单位: