STUDY OF MOTION SICKNESS INDUCED BY CORIOLIS STIMULATION AND PARABOLIC FLIGHT -ANALYSIS OF FACTORS INVOLVED IN ITS DEVELOPMENT AND SPATIAL ORIENTATION-

晕动病的发展过程涉及许多未知点。这项研究的目的是通过对运动病发展过程的全球分析来探讨运动病的中心病理。作为实现这一目标的一种手段，使用科里奥利刺激以高频率诱发晕动病，并从对该刺激的物理和生理反应中获得了许多发现。一项发现是，在导致晕动病的过程中，下丘脑-垂体激素会大量分泌，而没有经历过晕动病的人则不会有这种分泌。换句话说，运动病的发生与下丘脑-脑下垂体激素的分泌呈正相关。这种关系是通过使用国家航空航天发展局(NASDA)的设施和雇用大量健康的成年志愿者而新开发的。晕动病评分的优势是…更重要的是，它能够量化受试者对任务的反应，这是每个受试者都能理解的。这种方法比以前的方法更客观，适用于大量的受试者。此外，还研制了一种可以对主要由头部位置决定的重力轴和身体轴周围的空间方位进行定量分析的装置。使用该设备，分析了从晕动病发病前到发病后的空间定向。在重力轴的识别误差方面，所获得的数据与晕动病发作后的数据差异不显著，而与晕动病发作前相比，晕动病发作后对体轴的识别误差明显增加。这些结果似乎表明，在运动病的发展过程中，对重力轴和身体轴的识别错误增加。眼球反转测量(OCR)是一种主观分析耳石器官功能的方法。当通过图像分析测量OCR时，发现在易患运动病的受试者中，倾斜旋转的负荷导致不规则的OCR。此外，当沿重力轴和水平线分别给予期望诱发运动病的受试者(伪科里奥利)的视觉刺激时，几乎所有的晕动病症状都发生在沿重力轴的视觉刺激的反应中。另一方面，沿水平线的刺激，即与重力轴成最大角度的刺激，被发现肯定会引发晕车症状。较少

The process of development of motion sickness involved many unknown points. A goal of this study is to approach to the central pathology of motion sickness by means of global analysis of the process of its development. As a mean to achieve this, motion sickness was induced at high frequency using the Coriolis stimulation, and many findings were obtained from the physical and physiological reactions to the said stimulation. One finding is that the hypothalamus-pituitary hormone is vigorously secreted during the course leading to motion sickness, while no such secretion occurs in persons who do not experience motion sickness. In other words, there is a positive correlation between development of motion sickness and secretion of the hypothalamus-pituitary hormone. This relationship was confirmed using a newly developed using facilities of the National Aerospace Developmental Agency (NASDA) and employing a large number of healthy adult volunteers. The advantage of motion sickness score is … More that it is capable of quantifying the response of the subjects to the task which can be understood by each subject. This method was found to be more objective than the earlier method and applicable to large number of subjects. In addition, development was made of a device that can quantitatively analyze spatial orientation around the gravity axis and body axis mainly determined by the head position. Using this device, spatial orientation was analyzed from before through after onset of motion sickness. In terms of recognition errors of the gravity axis, the difference between the data obtained and after onset of motion sickness was not significant, while recognition errors regarding the body axis clearly increased after onset of motion sickness compared with that recorded before onset of motion sickness. These results seem to suggest involvement of increased recognition errors regarding the gravity axis and body axis in the development of motion sickness. There is measurement of ocular counter rolling (OCR) as a method of subjective analysis of the function of the otolith organ. When OCR was measured by image analysis, loading of oblique rotation was found to cause irregular OCR in subjects susceptible to motion sickness. Further, when visual stimulation was given separately along the gravity axis and horizontal line to the subjects with expectation to induced motion sickness (pseudo-Coriolis) , almost to symptoms of motion sickness occured in response to the visual stimulation along the gravity axis. On the other hand, stimulation along the horizontal line, the largest angle against the gravity axis, was found to definitely induce motion sickness symptoms. Less