STUDY OF MOTION SICKNESS INDUCED BY CORIOLIS STIMULATION AND PARABOLIC FLIGHT -ANALYSIS OF FACTORS INVOLVED IN ITS DEVELOPMENT AND SPATIAL ORIENTATION-

晕动病的发展过程涉及许多未知点。本研究的目的是通过对运动病发展过程的全面分析，探讨运动病的中枢病理学。作为实现这一点的手段，使用科里奥利刺激以高频率诱发运动病，并且从对所述刺激的物理和生理反应获得许多发现。一个发现是，下丘脑-垂体激素在导致运动病的过程中被剧烈分泌，而在没有经历运动病的人中没有这种分泌。换句话说，运动病的发生与下丘脑-垂体激素的分泌呈正相关。利用国家宇宙开发事业团的设施并雇用了大量健康的成年志愿者，使用新开发的一种方法证实了这种关系。晕动病评分的优点是 ...更多信息 它能够量化受试者对每个受试者都能理解的任务的反应。这种方法被认为比早期的方法更客观，适用于大量的受试者。此外，还开发了能够定量分析主要由头部位置决定的围绕重力轴和身体轴的空间方位的装置。使用该装置，从晕动病发作之前到之后分析空间定向。在识别错误的重力轴，所获得的数据之间的差异，并发病后的晕动病是不显着的，而识别错误的身体轴发病后的晕动病相比，发病前的记录明显增加。这些结果似乎表明，在运动病的发展中，重力轴和身体轴的识别错误增加。眼反滚动（OCR）的测量是一种主观分析耳石器官功能的方法。当通过图像分析测量OCR时，发现倾斜旋转的负载会导致易患晕动病的受试者的不规则OCR。此外，当分别沿沿着重力轴和水平线给予受试者视觉刺激以期望诱发运动病（伪科里奥利）时，几乎所有的运动病症状都响应于沿沿着重力轴的视觉刺激而发生。另一方面，发现沿水平线（相对于重力轴的最大角度）的沿着刺激肯定诱发晕动病症状。少

The process of development of motion sickness involved many unknown points. A goal of this study is to approach to the central pathology of motion sickness by means of global analysis of the process of its development. As a mean to achieve this, motion sickness was induced at high frequency using the Coriolis stimulation, and many findings were obtained from the physical and physiological reactions to the said stimulation. One finding is that the hypothalamus-pituitary hormone is vigorously secreted during the course leading to motion sickness, while no such secretion occurs in persons who do not experience motion sickness. In other words, there is a positive correlation between development of motion sickness and secretion of the hypothalamus-pituitary hormone. This relationship was confirmed using a newly developed using facilities of the National Aerospace Developmental Agency (NASDA) and employing a large number of healthy adult volunteers. The advantage of motion sickness score is … More that it is capable of quantifying the response of the subjects to the task which can be understood by each subject. This method was found to be more objective than the earlier method and applicable to large number of subjects. In addition, development was made of a device that can quantitatively analyze spatial orientation around the gravity axis and body axis mainly determined by the head position. Using this device, spatial orientation was analyzed from before through after onset of motion sickness. In terms of recognition errors of the gravity axis, the difference between the data obtained and after onset of motion sickness was not significant, while recognition errors regarding the body axis clearly increased after onset of motion sickness compared with that recorded before onset of motion sickness. These results seem to suggest involvement of increased recognition errors regarding the gravity axis and body axis in the development of motion sickness. There is measurement of ocular counter rolling (OCR) as a method of subjective analysis of the function of the otolith organ. When OCR was measured by image analysis, loading of oblique rotation was found to cause irregular OCR in subjects susceptible to motion sickness. Further, when visual stimulation was given separately along the gravity axis and horizontal line to the subjects with expectation to induced motion sickness (pseudo-Coriolis) , almost to symptoms of motion sickness occured in response to the visual stimulation along the gravity axis. On the other hand, stimulation along the horizontal line, the largest angle against the gravity axis, was found to definitely induce motion sickness symptoms. Less