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STUDY OF MOTION SICKNESS INDUCED BY CORIOLIS STIMULATION AND PARABOLIC FLIGHT -ANALYSIS OF FACTORS INVOLVED IN ITS DEVELOPMENT AND SPATIAL ORIENTATION-

科里奥利刺激和抛物线飞行引起的晕动病的研究-其发展和空间定向相关因素分析-

基本信息

批准号：
04671051
负责人：
ISHII Masamori
金额：
$ 1.34万
依托单位：
The Jikei University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1994
项目状态：
已结题

项目摘要

The process of development of motion sickness involved many unknown points. A goal of this study is to approach to the central pathology of motion sickness by means of global analysis of the process of its development. As a mean to achieve this, motion sickness was induced at high frequency using the Coriolis stimulation, and many findings were obtained from the physical and physiological reactions to the said stimulation. One finding is that the hypothalamus-pituitary hormone is vigorously secreted during the course leading to motion sickness, while no such secretion occurs in persons who do not experience motion sickness. In other words, there is a positive correlation between development of motion sickness and secretion of the hypothalamus-pituitary hormone. This relationship was confirmed using a newly developed using facilities of the National Aerospace Developmental Agency (NASDA) and employing a large number of healthy adult volunteers. The advantage of motion sickness score is … More that it is capable of quantifying the response of the subjects to the task which can be understood by each subject. This method was found to be more objective than the earlier method and applicable to large number of subjects. In addition, development was made of a device that can quantitatively analyze spatial orientation around the gravity axis and body axis mainly determined by the head position. Using this device, spatial orientation was analyzed from before through after onset of motion sickness. In terms of recognition errors of the gravity axis, the difference between the data obtained and after onset of motion sickness was not significant, while recognition errors regarding the body axis clearly increased after onset of motion sickness compared with that recorded before onset of motion sickness. These results seem to suggest involvement of increased recognition errors regarding the gravity axis and body axis in the development of motion sickness. There is measurement of ocular counter rolling (OCR) as a method of subjective analysis of the function of the otolith organ. When OCR was measured by image analysis, loading of oblique rotation was found to cause irregular OCR in subjects susceptible to motion sickness. Further, when visual stimulation was given separately along the gravity axis and horizontal line to the subjects with expectation to induced motion sickness (pseudo-Coriolis) , almost to symptoms of motion sickness occured in response to the visual stimulation along the gravity axis. On the other hand, stimulation along the horizontal line, the largest angle against the gravity axis, was found to definitely induce motion sickness symptoms. Less

晕动病的发展过程涉及许多未知的环节。本研究的目的是通过对晕动病发展过程的整体分析来探讨晕动病的核心病理。为了达到这一目的，我们使用高频率的科里奥利刺激诱发晕动病，并从对上述刺激的生理和生理反应中获得了许多发现。一项研究发现，在导致晕动病的过程中，下丘脑-垂体激素会大量分泌，而没有晕动病经历的人则不会分泌这种激素。换句话说，晕动病的发生与下丘脑-垂体激素的分泌呈正相关。这种关系是通过使用国家航空航天发展署（NASDA）新开发的设施和雇用大量健康的成年志愿者来证实的。晕动病评分的优势在于它能够量化受试者对每个受试者都能理解的任务的反应。该方法比以前的方法更客观，适用于大量的受试者。此外，还开发了一种可以定量分析以头部位置为主要决定因素的重力轴和身体轴周围空间方向的装置。使用这个装置，从晕动病发病前到发病后分析了空间取向。在重力轴的识别误差方面，获得的数据与发病后的数据差异不显著，而在身体轴的识别误差方面，发病后的数据与发病前相比明显增加。这些结果似乎表明，关于重力轴和身体轴的识别错误增加与晕动病的发展有关。有测量眼反转（OCR）作为一种主观分析耳石器官功能的方法。当图像分析测量OCR时，发现倾斜旋转的负荷导致运动病易感者的OCR不规则。此外，当沿重力轴和水平线分别给予预期诱发晕车（伪科里奥利）的受试者视觉刺激时，几乎所有的晕车症状都是在沿重力轴的视觉刺激下发生的。另一方面，沿着水平线的刺激，即与重力轴的最大角度，被发现肯定会诱发晕动病症状。少