The Study on the Chemical Structure of the Unusual Constituents of the Illicium Plants and its Chemotaxonomical studies

八角属植物异常成分的化学结构及其化学分类学研究

• 批准号: 04671296
• 负责人: KOUNO Isao
• 金额: $ 0.32万
• 依托单位: NAGASAKI UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04671296/
• 关键词: Illiciaceae; Illicium anisatum; Illicium majus; Illicium dunnianum; Illicium macranthum; Illicium simonsii; Illicium difengpi; Sesquiterpene; 紅八角(Illicium dunnianum); 南川八角(Illicium macranthum); Illicium simonsii; シキミ科; イリシウム属

Japanese Star Anise (Shikimi) (Illicium anisatum) is one of the toxic plants belonging to Illiciaceae, and is only one Illicium species in Japan. It is well known that the toxic compound of this plant is anisatin, which belongs to a unique sesquiterpene lactone and has the beta- and gamma-lactone moieties in the structure. The Illicium plant is distributed in the world only some 40 species. Among them, some 30 species are distributed in China.Investigation into the EtOH extract of the pericarps of a Chinese Illicium plant, Illicium majus, afforded tow new sesquiterpene lactones, designated as majucin and neomajucin, which has another unique structure along with anisatin. Two phytoquinoids and two neolignans were also isolated from this material.The study on the constituents from the pericarps of I.dunnianum, also a Chines Illicium plant, gave two new sesquiterpene lactones, which resembles to pseudoanisatin isolated from I.anisatum. This material also gave two new triphenylneolignans, dunnianin and isodunnianin.Other Chines Illicium plant, I.macranthum, was investigated, and a new triphenylneolignan was isolated, designated macranthol, together with a biphenylneolignan, magnolol, which was isolated from Magnolia obovata, Magnoliaceae. Another Chinese plant, I.simonsii has also gave a new triphenylneolignan.The Bark of I.difengpi is used as a folk medicine in China, and the EtoH extract gave many glyceroneolignans.

日本星星八角（Shikimi）（Illicium anisatum）是八角科有毒植物之一，也是日本唯一的八角属植物。众所周知，该植物的毒性化合物是茴香苷，其属于独特的倍半萜内酯，并且在结构中具有β-和γ-内酯部分。八角属植物在全世界仅分布40余种。从八角属（Illicium majus）植物的果皮乙醇提取物中分离得到两个新的倍半萜内酯类化合物，命名为majucin和neomajucin，它们与茴香苷具有沿着的独特结构。从八角属植物杜尼艾（I.dunnianum）果皮中分离得到两个新的倍半萜内酯类化合物，其结构类似于从八角茴香（I. anisatum）中分离得到的假茴香素（pseudoanisatin）。对中国八角属植物大花八角（I.macranthum）进行了研究，分离到一个新的三苯基新木脂素，命名为大花八角（I.macranthum），并从木兰科植物倒卵叶木兰（Magnolia obovata）中分离到一个联苯新木脂素，命名为木兰酚（Magnolol）。另一种中国植物小冬青（I.simonsii）也产生了一种新的三苯基新木脂素，地枫皮的树皮在中国被用作民间药物，其乙醇提取物产生了许多甘油新木脂素。

项目成果

"A New Triphenyl-type Neolignan and a Biphenylneolignan from the Bark of Illicium simonsii" Chem.Pharm.Bull.42. 112-114 (1994)

“来自八角茴香树皮的新型三苯基型新木脂素和联苯新木脂素”Chem.Pharm.Bull.42。

Isao KOUNO: "Phenylpropanoids from the Barks of Illicium difengpi" Chem.Pharm.Bull.40. 2461-2464 (1992)

Isao KOUNO：“来自八角茴香树皮的苯丙素”Chem.Pharm.Bull.40。

I.Kouno, Y.Yanagida, S.Shimono, M.Shintomi, Y.Ito and C.-S.Yang: "Neolignans and a Phenylpropanoid Glucoside from the Barks of Illicium difengpi" Phytochemistry. 32. 1573-1577 (1993)

I.Kouno、Y.Yanagida、S.Shimono、M.Shintomi、Y.Ito 和 C.-S.Yang：“来自八角茴香树皮的新木脂素和苯丙苷”植物化学。

Isao KOUNO: "Neolignans and a Phenylpropanoid Glucoside from the Bark of Illicium difengpi" Phytochemistry. 32. 1573-1577 (1993)

Isao KOUNO：“来自八角茴香树皮的新木脂素和苯丙苷”植物化学。

I.Kouno, Y.Yanagida, S.Shimono, M.Shintomi and C.-S.Yang: "Phenylpropanoids from the Barks of Illicium difengpi" Chem.Pharm.Bull. 40. 2461-2464 (1992)

I.Kouno、Y.Yanagida、S.Shimono、M.Shintomi 和 C.-S.Yang：“来自八角茴香树皮的苯丙素”Chem.Pharm.Bull。