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New Type of Polyphenolic Compounds Targeting for Healthy Food-stuff

针对健康食品的新型多酚化合物

基本信息

批准号：
18590006
负责人：
KOUNO Isao
金额：
$ 2.49万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

项目摘要

Previous studies on the aerial part and under-ground part of Balanophora japonica have resulted in the isolation of five lignans, ten kinds of esterified glucoside together with a well-known compound, caffeic acid. In this study, we examined the enzyme inhibitory activities of these 16 compounds using two in vitro assay systems with lipoxygenase and hyaluronidase.It is believed that the biological activities of phenolic functional groups are attributable to their phenolic functional groups. The most important and well-known role of the function for human health is probably the antioxidant activity. Antioxidants like phenols can remove radical intermediate in human body and can prevent other oxidation reactions by oxidizing themselves. Other important role of phenol compound for human health is thought to be some enzyme inhibitory activities. For the purpose of verification of this expected activities, we examined the inhibitory effect of some isolated compounds from B. japonica on lipoxygenase and hyaluronidase activities, respectively.We conclude that with respect to the inhibition activity of hyaluronidase, 1,2-di-O-caffeoyl glucose had the most potent activity. On the other hand, in the case of lipoxygenase inhibitory activity, 1-O-caffeoyl 6-O-galloyl glucose had the most potent activity.Thus, although it is necessary to verify any kind of toxicity for this plant, there is no doubt that this parasitic plant, Balanophora japonica, would have the possibility of being a healthy food-stuff.

前期对蛇杖地上部分和地下部分的研究已分离出5种木脂素、10种酯化葡萄糖苷以及一种著名的化合物咖啡酸。在本研究中，我们使用脂氧合酶和透明质酸酶两种体外测定系统检测了这16种化合物的酶抑制活性。据认为，酚类官能团的生物活性归因于它们的酚类官能团。该功能对人类健康最重要和众所周知的作用可能是抗氧化活性。酚类等抗氧化剂可以清除人体内的自由基中间体，并可以通过自身氧化来阻止其他氧化反应。酚类化合物对人类健康的其他重要作用被认为是某些酶的抑制活性。为了验证这种预期活性，我们检测了一些从 B. japonica 中分离的化合物分别对脂氧合酶和透明质酸酶活性的抑制作用。我们得出结论，对于透明质酸酶的抑制活性，1,2-二-O-咖啡酰葡萄糖具有最强的活性。另一方面，在脂氧合酶抑制活性的情况下，1-O-咖啡酰6-O-没食子酰葡萄糖具有最强的活性。因此，尽管有必要验证这种植物的任何毒性，但毫无疑问，这种寄生植物，Balanophora japonica，有可能成为健康食品。