A New Drug Delivery System (DDS) Developement Using Plasma-Irradiated Pharmaceutical Aids

1. 我们对多种合成聚合物进行了氩等离子体辐照，探索等离子体处理的分子机制，并借助电子自旋共振（ESR）研究了形成的残留物，并进行了系统的计算机模拟。通过这个研究项目，我们已经阐明了等离子体诱导的粉末聚乙烯（PE）、聚碳酸酯（PC）等聚缩聚聚合物和肌醇的表面自由基的性质，为各种聚碳水化合物自由基的初步研究奠定了基础。以茶碱片为核心材料，PC粉为单壁材料制备的等离子辐照双压缩片剂的溶出曲线可以根据所选择的片剂制造条件和等离子体操作条件的不同，以不同的速度释放药物。3 .以聚乳酸（PLA）和聚甲醛（POM）为外层的等离子辐照双压缩片剂可应用于皮下组织的可植入剂型。4 .外层由具有可交联侧链的可降解聚合物（甲基丙烯酸甲酯和甲基丙烯酸甲酯共聚物）组成的等离子辐照双压缩片的溶出曲线不仅取决于等离子体操作条件，还取决于共聚物的组成。研究发现，等离子体辐照PE的机械振动引起了自由基复合反应，导致粒子间的相互连接。因此，由等离子体辐照PE和茶碱的机械振动制备的复合粉末的溶解谱由等离子体辐照PE的自由基浓度控制。希望在目前正在进行的工作过程中，能够开发出适用于广泛药物和聚合物的进一步设备，以检查等离子体辐照DDS制造的有用性。

1. We have undertaken Ar plasma irradiation on a variety of synthetic polymers to explore the molecular mechanism of plasma treatment, and the redicals formed were studied by electron spin resonance (ESR) with the aid of systematic computer simulations. Through this research project, we have elucidated the nature of plasma-induced surface radicals of powdered polyethylene (PE), polycondensed polymer such as polycarbonate (PC) and myo-inositol for an initial study of various polycarbohydrate radicals.2. The dissolution profiles of plasma-irradiated double-compressed tablets prepared from a thephylline tablet as a core material and PC powder as a single wall material can be varied so as to allow release of the drug at different rates, depending on the set of conditions chosen for tablet manufacturing and plasma operational conditions.3. The plasma-irradiated couble-compressed tablets consisting of poy-DL-latic acid (PLA) and polyoxymethylene (POM) as the outer layr can be applied to an implantable dosage form in the subcutaneous tissue.4. The dissolution profiles of the plasma-irradiated double-compressed tablets with the outer layr consisting of a degradable polymer possessing a crosslinkable side chain (benzylmethacrylate and methylmethacrylate copolymer) depends on not only plasma operational conditions but also the copolymer composition.5. It was found that the mechanical vibration of the plasma-irradiated PE caused the radical recombination reaction resulting in the interlinking between the paricles. Thus, the dissolution profile of the comosite powder prepared by the mechanical vibration of the plasma-irradiated PE and theophylline is controlled by the radical concentration of the plasma-irradiated PE.It is hoped that further devices applicable to a wide range of drugs and polymers will be developed in the course of work now in progress to examine the usefulness of plasma-irradiation of DDS fabrications.