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A New Drug Delivery System (DDS) Developement Using Plasma-Irradiated Pharmaceutical Aids

使用等离子体辐照药物辅助剂开发新的药物输送系统 (DDS)

基本信息

批准号：
04671327
负责人：
KUZUYA Masayuki
金额：
$ 1.28万
依托单位：
Gifu Pharmaceutical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1993
项目状态：
已结题

项目摘要

1. We have undertaken Ar plasma irradiation on a variety of synthetic polymers to explore the molecular mechanism of plasma treatment, and the redicals formed were studied by electron spin resonance (ESR) with the aid of systematic computer simulations. Through this research project, we have elucidated the nature of plasma-induced surface radicals of powdered polyethylene (PE), polycondensed polymer such as polycarbonate (PC) and myo-inositol for an initial study of various polycarbohydrate radicals.2. The dissolution profiles of plasma-irradiated double-compressed tablets prepared from a thephylline tablet as a core material and PC powder as a single wall material can be varied so as to allow release of the drug at different rates, depending on the set of conditions chosen for tablet manufacturing and plasma operational conditions.3. The plasma-irradiated couble-compressed tablets consisting of poy-DL-latic acid (PLA) and polyoxymethylene (POM) as the outer layr can be applied to an implantable dosage form in the subcutaneous tissue.4. The dissolution profiles of the plasma-irradiated double-compressed tablets with the outer layr consisting of a degradable polymer possessing a crosslinkable side chain (benzylmethacrylate and methylmethacrylate copolymer) depends on not only plasma operational conditions but also the copolymer composition.5. It was found that the mechanical vibration of the plasma-irradiated PE caused the radical recombination reaction resulting in the interlinking between the paricles. Thus, the dissolution profile of the comosite powder prepared by the mechanical vibration of the plasma-irradiated PE and theophylline is controlled by the radical concentration of the plasma-irradiated PE.It is hoped that further devices applicable to a wide range of drugs and polymers will be developed in the course of work now in progress to examine the usefulness of plasma-irradiation of DDS fabrications.

1.我们已经进行了Ar等离子体辐照各种合成聚合物，探索等离子体处理的分子机制，并形成的自由基进行了研究，通过电子自旋共振（ESR）与系统的计算机模拟的帮助下。通过本研究项目，我们阐明了等离子体诱导的粉末聚乙烯（PE）、缩聚聚合物如聚碳酸酯（PC）和肌醇的表面自由基的性质，为各种聚碳水化合物自由基的初步研究.由茶碱片剂作为芯材料和PC粉末作为单壁材料制备的等离子体照射的双重压缩片剂的溶出曲线可以变化，以允许药物以不同的速率释放，这取决于为片剂制造选择的一组条件和等离子体操作条件。等离子体辐照的双层压片由聚DL-乳酸（PLA）和聚甲醛（POM）作为外层组成，可以应用于皮下组织中的植入剂型。外层由具有可交联侧链的可降解聚合物（甲基丙烯酸苄酯和甲基丙烯酸甲酯共聚物）组成的等离子体辐照双层压片的溶出曲线不仅取决于等离子体操作条件，还取决于共聚物组成。结果表明，等离子体辐照聚乙烯的机械振动引起自由基复合反应，导致粒子之间的相互连接。因此，由等离子体辐照的PE和茶碱的机械振动制备的comosite粉末的溶解曲线由等离子体辐照的PE的自由基浓度控制。希望在目前正在进行的工作过程中开发适用于广泛的药物和聚合物的进一步设备，以检查DDS制造的等离子体辐照的有用性。