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Study on prevention of hepatitis C for hepatitis C viral infection

丙型肝炎病毒感染的预防研究

基本信息

批准号：
06670408
负责人：
OHTA Setsuko
金额：
$ 1.41万
依托单位：
Shinshu University, School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06670408/
关键词：
Hepatitis C Virus (HCV)Prevention of Hepatitis C Latent Infection Liver function Atibody to HCV Inhabitants HCV Endemic Area Alcohol Drinking Epidemiological Survey C型肝炎ウイルス(HCV)発病予防保健管理システム栄養摂取状況労働生活スタイル

项目摘要

In order to set up a program for people with latent hepatitis C virus (HCV) infection, this investigation was projected through epidemiological survey in the HCV endemic area where the prevalence of HCV infection was found to be 32.4%. From the survey in September 1994 and 1995, we obtained following results ;1.The levels of GOT,GPT,ZTT and TTT were increased with the increase of titer of anti-HCV in both sexes, whereas those of total-choresterol and triglyceride were decreased.2.Higher levels were found more frequently in alcohol drinkers than in nondrinkers. In nondrinkers with HCV infection, total-and HDL-choresterol and triglyceride were normal levels, but in drinkers with HCV infection, these indicators were decreased. These results suggest that alcohol drinking accentuates the development of liver injury even in people with latent HCV infection.3.gammaGTP was more sharply increased in relation to alcohol intake in people with HCV infection than in healthy people, suggesting that HCV infection affects alcohol-induced liver damage.4.These results suggest that alcohol drinking and HCV infection concomitantly facilitate the development of hepatitis.These results were presented at the 5th and the 6th annual meeting of the Japan epidemiological association (January 1995,1996) , and the 65th and the 66th annual meeting of the Japanese society for hygiene(March 1995, May 1996).

为了制定针对丙型肝炎病毒（HCV）潜伏感染者的规划，本次调查是通过对丙型肝炎病毒流行区的流行病学调查进行预测，该地区的丙型肝炎病毒感染率为32.4%。通过1994年9月和1995年9月的调查，我们得到以下结果：1.男女GOT、GPT、ZTT、TTT水平随着抗HCV滴度的升高而升高，而总胆固醇和甘油三酯则降低。2.饮酒者中GOT、GPT、ZTT、TTT水平升高的频率高于不饮酒者。在感染 HCV 的不饮酒者中，总胆固醇、高密度脂蛋白胆固醇和甘油三酯处于正常水平，但在感染 HCV 的饮酒者中，这些指标均下降。这些结果表明，即使在潜伏性 HCV 感染者中，饮酒也会加剧肝损伤的发展。3.HCV 感染者中，与健康人相比，与酒精摄入量相关的 γGTP 增加更为急剧，这表明 HCV 感染会影响酒精引起的肝损伤。4.这些结果表明，饮酒和 HCV 感染同时会促进肝炎的发展。这些结果于第 5 日和第 5 日发表。日本流行病学会第6次年会（1995年1月、1996年）、日本卫生学会第65次、第66次年会（1995年3月、1996年5月）。