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^<31>P Chemical Shift Imaging for Quantitative Measurements of Cardiac High-Energy Phosphate

^<31>用于心脏高能磷酸盐定量测量的 P 化学位移成像

基本信息

批准号：
06670711
负责人：
MITSUNAMI Kenichi
金额：
$ 1.34万
依托单位：
Shiga University of Medical Science
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06670711/
关键词：
^<31>P NMR spectroscopy Chemical shift imaging High-energy phosphate Quantification Human myocardium Ischemic heart disease Myochardial viability MRS 1D CSI

项目摘要

The aims of this study were to determine whether or not quantitative measurements of cardiac high-energy phosphate by ^<31>P chemical shift imaging (CSI) are useful in assessing myocardial viability and to clarify which CSI technique is the most suitable. The one-dimensional CSI study group was composed of 41 patients with stenosis of the left anterior descending coronary artery (>50%) and 11 healthy control subjects (C). The patients were divided into two groups on the basis of exercise ^<201>Tl scintigraphy : a reversible ^<201>Tl defect group (RD [+] , N=29) and a fixed ^<201>Tl defect group (RD [-] , n=12). Cardiac ^<31>P magnetic resonance spectra were obtained by slice-selected one-dimensional CSI.For metabolite quantification a standard was placed at the center of the surface coil. ANOVA revealed significant differences among the three groups with respect to mean (<plus-minus>SD) phosphocreatine at rest (C,12.14<plus-minus>4.25>RD [+] , 7.64<plus-minus>3.00>RD [-] , 3.94<plus-mi … More nus>2.21 mumol/g wet heart tissue, p<0.05) as well as a significant decrease in ATP in the RD [-] group (C,7.72<plus-minus>2.97 ; RD [+] , 6.35<plus-minus>3.17>RD [-] , 4.35<plus-minus>1.52 mumol/g wet heart tissue, p<0.05). When a two-dimensional phase encoding technique with slice-selective excitation in the axial direction was used to measure the concentration of inorganic phosphate in the phantom, it yielded very accurate results. When the same technique, however, was applied to human heart, each voxel (2.5x2.5x2.5-cm^3) was often not totally filled with myocardium. This led to difficulties in estimating the myocardial weight in the voxel. It was impossible to place a standard within the sensitive volume of the surface coil when employing a two-dimensional phase encoding technique with slice-selective excitation in the coronal direction. Thus, one-dimensional CSI with sagittal slice-selective excitation is the most suitable CSI technique for cardiac metabolite measurements and is useful for the evaluation of myocardial viability. Less

本研究的目的是确定用化学位移成像(CSI)定量测量心脏高能磷酸盐是否有助于评估存活心肌，并明确哪种CSI技术是最合适的。一维CSI研究组包括41例冠状动脉左前降支狭窄患者(&gt；50%)和11例健康对照组(C)。根据运动试验将患者分为两组：可逆性Tl缺陷组(Rd[+]，N=29)和固定组(Rd[-]，n=12)。心脏磁共振波谱通过层析选择的一维CSI获得。对于代谢物定量，在表面线圈的中心放置标准。方差分析显示，三组之间在静息(++)磷酸肌酸平均值(C，12.14；+->RD[+]，7.64；+->；3.00&>RD[-]，3.94&lt；+-mi…)方面存在显著差异更多的NUS&gt；2.21mumol/g湿心组织，p&lt；0.05)，以及在RD[-]组(C，7.72；正负&gt；2.97；RD[+]，6.35&lt；正负&gt；3.17&gt；RD[-]，4.35&lt；正负&gt；1.52 mumol/g湿心组织，p&lt；0.05)。采用轴向切片选择激发的二维相位编码技术测量体模中无机磷的浓度，得到了非常准确的结果。然而，当同样的技术应用于人的心脏时，每个体素(2.5x2.5x2.5-cm^3)通常不是完全充满心肌。这导致了估计体素中的心肌重量的困难。当使用在冠状方向上具有切片选择性激发的二维相位编码技术时，不可能将标准放在表面线圈的敏感体积内。因此，矢状面选择性激发的一维CSI是测量心脏代谢物的最合适的CSI技术，并可用于评估心肌存活性。较少