Role of endothelium-derived nitric oxide on regulation of coronary blood flow

内皮源性一氧化氮对冠脉血流调节的作用

• 批准号: 06670730
• 负责人: OKUMURA Ken
• 金额: $ 1.47万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06670730/
• 关键词: Endothelium; Nitric Oxide; L-arginine; Coronary Circulation; L-Arginine

To clarify the role of endotheliun-derived nitric oxide (EDNO) on regulation of coronary blood flow, we performed in-vivo study with anesthetized dogs. We have revealed that EDNO is likely to play a role in the regulation of the basal coronary blood flow (Arch int Pharmacodyn 1994 ; 327 : 251-265) , and the myocardial reactive hyperemia is regulated not only by adenosine but also by the EDNO.(Am J Physiol 1992 ; 263 : H8-H14、Cardiovascular Res 1996 in press) We also showed that when NO synthesis is inhibited, adenosine release is increased in response to themyocardial oxygen demand. With this compensatory adenosine release, coronary flow is increased and ventricular function is unaffected. (Am J Physiol 1996 ; 270 : H427-H434) Chronic inhibition of nitric oxide formation with oral administration of L-NAME,L-arginine analogue, blunted coronary reactive hyperemia, but didnot substantially impair the coronary blood flow associated with increased myocardial oxygen requirements produced by atrial pacing. We have revealed that adenosine is likely to play a role in this conpensation. (60th annual meeting of Japanese circulation society, 1996)

为了阐明内皮源性一氧化氮（EDNO）在冠状动脉血流调节中的作用，我们用麻醉犬进行了在体研究。我们已经揭示，EDNO可能在基础冠状动脉血流量的调节中起作用（Arch int Pharmacodyn 1994 ; 327：251-265），并且心肌反应性充血不仅由腺苷调节，而且也由EDNO调节。(Am J Physiol 1992 ; 263：H8-H14，Cardiovascular Res 1996 in press）我们还表明，当NO合成被抑制时，腺苷释放响应于心肌氧需求而增加。随着这种代偿性腺苷释放，冠状动脉流量增加，心室功能不受影响。(Am J Physiol 1996 ; 270：H427-H434）口服L-精氨酸类似物L-NAME慢性抑制一氧化氮形成，可减弱冠状动脉反应性充血，但对与心房起搏引起的心肌需氧量增加相关的冠状动脉血流无实质性损害。我们已经发现，腺苷可能在这种代偿中发挥作用。(60th日本流通学会年会，1996年）

项目成果

Okumura K.et al.: "Effect of Brain (B-type) natriuretic peptide on coronary artery diameter and coronary hemodynamic variables in humans : comparison with effects on systemic hemodynamic variables" J Am Coll Cardiol. 25. 342-348 (1995)

Okumura K.等人：“脑（B 型）利钠肽对人类冠状动脉直径和冠状动脉血流动力学变量的影响：与对全身血流动力学变量的影响进行比较”J Am Coll Cardiol。

T.Matsunaga et al.: "Effect of Cumulative Doses of NG-Nitro-L-Arginine Methyl Ester on Coronary Blood Flow of Anesthetized and Conscious Dogs" Archives internationales de Pharmacodynamie et de Therapie. 327. 251-265 (1994)

T.Matsunaga 等人：“NG-硝基-L-精氨酸甲酯对麻醉和清醒狗的冠状动脉血流的累积剂量的影响”Archives Internationales de Pharmacodynamie et de Therapie。

K.Okumura et al.: "Effects of Brain(B-Type)Natriuretic Peptide on Coronary Artery Diameter and Coronary Hemodynamic Variables in Humans:Comparison With Effects on Systemic Hemodynamic Variables" J.Am.Coll.Cardiol.25. 342-348 (1995)

K.Okumura 等人：“脑（B 型）钠尿肽对人类冠状动脉直径和冠状血流动力学变量的影响：与对全身血流动力学变量的影响的比较”J.Am.Coll.Cardiol.25。

Matsunaga T, et al.: "Effect of cumulative dose of NG-intro-L-arginine methyl ester on coronary blood flow of anesthetized and conscious dogs." Arch Int Pharmacody. 327. 251-265 (1994)

Matsunaga T 等人：“NG-intro-L-精氨酸甲酯累积剂量对麻醉和清醒狗冠状动脉血流的影响。”

Matsunaga T, et al.: "Role of adenosine in regulation of coronary flow in dogs with inhibited synthesis of endothelium-derived nitric oxide" Am J Physiol. 270. H427-H434 (1996)

Matsunaga T 等人：“腺苷在狗冠脉血流调节中的作用，可抑制内皮源性一氧化氮的合成”Am J Physiol。