L-ARGININE SUPPLEMENTATION IN THE ELDERLY-NITRIC OXIDE

老年人补充L-精氨酸-一氧化氮

• 批准号: 6050758
• 负责人: John V. Weil
• 金额: $ 7.55万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6050758
• 关键词: aminoacid analyzer; appetite; arginine; attention; blood chemistry; clinical research; clinical trials; dietary aminoacid; dietary supplements; echocardiography; functional ability; human old age (65+); human subject; nitric oxide; nutrition related tag; sleep; vascular endothelium; vasodilation

Current experimental evidence points to the importance of nitric oxide in the preservation of normal vascular function and structure, blood pressure, sleep, appetite, and sexual function. It is also clear that nitric oxide activity is impaired in a wide array of cardiovascular disorders and that this deficit responds to administration of L-arginine, the sole substrate for generation of nitric oxide. Published studies in animals and our own preliminary findings in humans show that L-arginine levels decline with aging and could thus constitute a reversible contributor to development and progression of vascular dysfunction and other features of aging. We have also found that in the elderly, nutritional L-arginine supplementation can raise serum L-arginine levels to values comparable to those in younger subjects, but the functional implications of this effect remain unknown. This one year pilot proposal seeks to determine whether raising serum L-arginine levels with nutritional supplementation leads to increases in markers of nitric oxide activity, enhances endothelial, nitric oxide-mediated vasodilator function, and possibly improves subjective self-assessments of quality of sleep, daytime alertness, and appetite. This work could provide a theoretical foundation for studies of longer term supplementation with safe, inexpensive agents which could preserve cardiovascular and other functions in the elderly.

目前的实验证据表明，一氧化氮在维持正常血管功能和结构、血压、睡眠、食欲和性功能方面的重要性。同样清楚的是，一氧化氮活性在一系列心血管疾病中受损，这种缺陷与l -精氨酸（生成一氧化氮的唯一底物）的使用有关。已发表的动物研究和我们在人类身上的初步发现表明，l -精氨酸水平随着年龄的增长而下降，因此可能对血管功能障碍和其他衰老特征的发展和进展产生可逆的影响。我们还发现，在老年人中，营养补充l -精氨酸可以将血清l -精氨酸水平提高到与年轻人相当的水平，但这种效果的功能含义尚不清楚。这项为期一年的试点计划旨在确定通过营养补充提高血清l -精氨酸水平是否会导致一氧化氮活性标志物的增加，增强内皮、一氧化氮介导的血管舒张功能，并可能改善对睡眠质量、白天警觉性和食欲的主观自我评估。这项工作为研究长期补充安全、廉价的药物以保护老年人的心血管和其他功能提供了理论基础。

项目成果

Multiscale modeling in the clinic: diseases of the brain and nervous system.

• DOI: 10.1007/s40708-017-0067-5
• 发表时间: 2017-12
• 期刊: Brain informatics
• 作者: Lytton WW;Arle J;Bobashev G;Ji S;Klassen TL;Marmarelis VZ;Schwaber J;Sherif MA;Sanger TD
• 通讯作者: Sanger TD